103667-54-5

Basic information

• Product Name: 3H,5H-Pyrrolo[1,2-c]oxazol-5-one, tetrahydro-3-phenyl-
• CAS NO: 103667-54-5
• Molecular Formula: C12H13NO2
• Molecular Weight: 203.241
• Mol File: 103667-54-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3H,5H-Pyrrolo[1,2-c]oxazol-5-one, tetrahydro-3-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 3H,5H-Pyrrolo[1,2-c]oxazol-5-one, tetrahydro-3-phenyl-(103667-54-5)
• EPA Substance Registry System: 3H,5H-Pyrrolo[1,2-c]oxazol-5-one, tetrahydro-3-phenyl-(103667-54-5)

Safety Data

• Hazardous Substances Data: 103667-54-5(Hazardous Substances Data)

Upstream product

• 100-52-7 benzaldehyde 
• 62400-75-3 pyroglutamol 

Downstream Products

• 108827-55-0 (4S,6aR,10R,12aS)-4,10-Diphenyl-octahydro-5,11-dioxa-3a,9a-diaza-dicyclopenta[a,f]cyclodecene-3,9-dione 
• 1601475-93-7 C₃₃H₄₄F₃N₃O₆ 
• 1000894-85-8 C₂₀H₂₆F₃NO₅ 
• 1000894-83-6 C₁₂H₂₁NO₃ 
• 130092-20-5 (trans)-4-cyclohexyl-L-proline 

Relevant articles and documents

A MESO SPECIFIC REACTION

Acid-catalyzed condensation of optically pure 5-(hydroxymethyl)-2-pyrrolidinone, 2, with benzaldehyde gives only a monomeric optically active oxazolidine, 3, while under the same conditions, racemic 2 gives only a meso centrosymmetric compound 4 - a dimer of racemic 3.This meso specific reaction serves as a highly efficient method for increasing the optical purity of the generally useful chiral building blocks 2 and 3.

Process and intermediates for preparing trans-4-substituted-s-prolines

4-Substituted proline derivatives having the formula STR1 can be prepared by reacting the compound having the formula STR2 with a compound having the formula STR3 to obtain a compound having the formula STR4 (a novel intermediate), alkylating that compoun