1037147-97-9

Basic information

• Product Name: 2-[(4-Fluorophenyl)sulfonyl]acetic acid ethyl ester
• Synonyms: 2-[(4-Fluorophenyl)sulfonyl]acetic acid ethyl ester
• CAS NO: 1037147-97-9
• Molecular Formula: C₁₀H₁₁FO₄S
• Molecular Weight: 246.2553432
• Mol File: 1037147-97-9.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• Density: 1.306
• CAS DataBase Reference: 2-[(4-Fluorophenyl)sulfonyl]acetic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(4-Fluorophenyl)sulfonyl]acetic acid ethyl ester(1037147-97-9)
• EPA Substance Registry System: 2-[(4-Fluorophenyl)sulfonyl]acetic acid ethyl ester(1037147-97-9)

Safety Data

• Hazardous Substances Data: 1037147-97-9(Hazardous Substances Data)

Usage

Type of compound

Sulfonyl acetic acid ester

Substituent

4-fluorophenyl

Potential applications

Medicinal and pharmaceutical fields, synthesis of pharmaceuticals and bioactive compounds

Precautions

May pose risks to human health and the environment if not properly managed

Further action needed

Research and testing to understand potential uses and risks

Upstream product

• 349-88-2 4-Fluorobenzenesulfonyl chloride 
• 105-36-2 ethyl bromoacetate 
• 824-80-6 sodium 4-fluorobenzenesulfinate 
• 141-97-9 ethyl acetoacetate 
• 623-73-4 diazoacetic acid ethyl ester 
• 2266-41-3 4-fluorobenzenesulfonylhydrazide 
• 105-39-5 chloroacetic acid ethyl ester 
• 371-42-6 4-Fluorothiophenol 
• 78066-05-4 ethyl 2-(p-fluorophenylthiaoxy)acetate 

Downstream Products

• 36107-09-2 ((4-fluorophenyl)sulfonyl)acetohydrazide 
• 1004770-25-5 2-(4-fluoro-benzenesulfonyl)-2-methyl-propionic acid ethyl ester 
• 383-38-0 p-fluorophenylsulphonylacetic acid 
• 66074-02-0 3,4-bis(4-fluorobenzene-1-sulfonyl)furoxan 

Relevant articles and documents

Synthesis and biological evaluation of 2-(4-substituted benzene-1-sulfonyl)-N'-(substituted-1-sulfonyl)acetohydrazide as antibacterial agents

In this study, a series of new sulfone derivatives containing a sulfonohydrazide moiety were synthesized and their structures were determined using 1H NMR, 13C NMR, and HRMS. Then, the in vitro antibacterial activities against Xanthomonas oryzae pv. oryzae (Xoo) and Xanthomonas axonopodis pv. citri (Xac) were evaluated by performing turbidimeter test. Bioactivity results showed that compound 2-(4-fluorobenzene-1-sulfonyl)-N′-(4-fluorobenzene-1-sulfonyl)acetohydrazide (5g) revealed the best antibacterial activities against Xoo and Xac, with the 50percent effective concentration (EC50) values of 25 and 36?μg/mL, respectively, which were superior to those of thiodiazole copper (110 and 230?μg/mL, respectively) and bismerthiazol (84 and 146?μg/mL, respectively).

Cross coupling of sulfonyl radicals with silver-based carbenes: A simple approach to β-carbonyl arylsulfones

A coupling reaction between sulfonyl radicals and silver-based carbenes has been well established. This simple radical-carbene coupling (RCC) process provided an efficient approach to a variety of β-carbonyl arylsulfones from sodium arylsulfinates and diazo compounds, and was characterized by wide substrate scope, easy scale-up, simple manipulation, accessible starting materials, and mild reaction conditions.

Design, Synthesis, and Evaluation of New Sulfone Derivatives Containing a 1,3,4-Oxadiazole Moiety as Active Antibacterial Agents

This study aimed to synthesize some new sulfone derivatives containing a 1,3,4-oxadiazole moiety and investigate their in vitro antibacterial activities against Xanthomonas oryzae pv. oryzae (Xoo) and Xanthomonas axonopodis pv. citri (Xac), the pathogens