103831-07-8

Basic information

• Product Name: O-methyl 3-(p-methoxyphenyl)propanohydroxamate
• Synonyms: O-methyl 3-(p-methoxyphenyl)propanohydroxamate
• CAS NO: 103831-07-8
• Molecular Weight: 209.245
• Mol File: 103831-07-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: O-methyl 3-(p-methoxyphenyl)propanohydroxamate(CAS DataBase Reference)
• NIST Chemistry Reference: O-methyl 3-(p-methoxyphenyl)propanohydroxamate(103831-07-8)
• EPA Substance Registry System: O-methyl 3-(p-methoxyphenyl)propanohydroxamate(103831-07-8)

Safety Data

• Hazardous Substances Data: 103831-07-8(Hazardous Substances Data)

Upstream product

• 1929-29-9 3-(4-methoxyphenyl)propanoic acid 
• 112404-06-5 potassium p-methoxycinnamohydroxamate 
• 593-56-6 N-methoxylamine hydrochloride 
• 112404-07-6 O-methyl p-methoxycinnamohydroxamate 
• 112403-71-1 O-methyl N-chloro-3-(p-methoxyphenyl)propanohydroxamate 
• 15893-42-2 3-(4-methoxyphenyl)propionyl chloride 

Downstream Products

• 686723-63-7 1,4-dioxa-9-azadispiro[4.2.48.25]tetradecan-10-one 
• 112403-71-1 O-methyl N-chloro-3-(p-methoxyphenyl)propanohydroxamate 

Relevant articles and documents

N-methoxy-N-acylnitrenium ions: Application to the formal synthesis of (±)-desmethylamino FR901483

(matrix presented) The formal synthesis of (±)-desmethylamino FR901483 (2) is described. Construction of the unique azatricyclic skeleton of 2 was accomplished by a sequence which involved (i) preparation of dienone 7 by an N-methoxy-N-acylnitrenium ion-i

Electrophilic Aromatic Substitution with N-Methoxy-N-acylnitrenium Ions Generated from N-Chloro-N-methoxyamides: Syntheses of Nitrogen Heterocyclic Compounds Bearing a N-Methoxyamide Group

N-Methoxy-N-acylnitrenium ions (II), generated by treatment of N-chloro-N-methoxyamides with silver carbonate in trifluoroacetic acid, react with arenes to give N-aryl-N-methoxyamides in good yields.In the case of the intramolecular cyclization of N-chloro-N-methoxy-2-phenylacetamides, the mode of cyclization is highly dependent on the nature of ortho or para substituent groups.Nitrenium ions II can primarily attack three positions (C-1, C-2, and C-6) of a phenyl ring.Normally II attack C-6.On the other hand, when the ortho position was occupied with a substituent group, II attacked both C-2 and C-6, in the former case followed by a 1,2-substituent migration, which was proved by a deuterium labeling experiment.Especially, when a methoxy group is substituted on ortho or para position, II attack C-1 due to the effect of the electron-releasing methoxy group to give spiro dienone compounds 39.A general discussion of the utility and mechanistic details of these reactions is presented.