10384-20-0Relevant articles and documents
Regio- and diastereoselective reduction of nonenolizable α-diketones to acyloins mediated by indium metal
Khan, Faiz Ahmed,Dash, Jyotirmayee,Sahu, Nilam,Gupta, Sharad
, p. 1015 - 1018 (2007/10/03)
(equation presented) α-Diketones are efficiently reduced with indium metal in methanol-water in the presence of NH4Cl, LiCl, or NaCl to give regio-and diastereoselectively the corresponding acyloins in good to excellent yield. The cleavage of the acyloins under Pb(OAc)4MeOH-PhH condition provides a convenient and regioselective access to highly functionalized cyclopentane carboxaldehydes, potential building blocks in organic syntheses.