103842-00-8

Basic information

• Product Name: N-(2-fluoro-4-hydroxyphenyl)acetamide
• CAS NO: 103842-00-8
• Molecular Formula: C₈H₈FNO₂
• Molecular Weight: 169.153
• Mol File: 103842-00-8.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 373.8°C at 760 mmHg
• Flash Point: 179.8°C
• Density: 1.351g/cm³
• Vapor Pressure: 4.07E-06mmHg at 25°C
• Refractive Index: 1.592
• CAS DataBase Reference: N-(2-fluoro-4-hydroxyphenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-fluoro-4-hydroxyphenyl)acetamide(103842-00-8)
• EPA Substance Registry System: N-(2-fluoro-4-hydroxyphenyl)acetamide(103842-00-8)

Safety Data

• Hazardous Substances Data: 103842-00-8(Hazardous Substances Data)

Usage

Uses

Used in Medicinal Chemistry:
N-(2-fluoro-4-hydroxyphenyl)acetamide is utilized as a building block for the synthesis of various drug candidates and bioactive compounds, particularly in the development of anti-cancer and anti-infective agents. Its unique molecular structure, which includes a fluorine atom and a hydroxy group, contributes to its potential as a promising candidate in drug discovery and development.
Used in Pharmaceutical Research:
In pharmaceutical research, N-(2-fluoro-4-hydroxyphenyl)acetamide serves as a key component in the creation of novel therapeutic agents. Its distinctive structural features make it a valuable asset in the advancement of treatments for a range of diseases.
Used in Organic Synthesis:
N-(2-fluoro-4-hydroxyphenyl)acetamide is employed as a reagent in organic synthesis, where its unique structural attributes facilitate chemical reactions and the formation of new compounds.
Used in Chemical Reactions:
As a versatile chemical compound, N-(2-fluoro-4-hydroxyphenyl)acetamide is also used in various chemical reactions, capitalizing on its structural features to drive the synthesis of diverse chemical entities.

Upstream product

• 399-95-1 4-amino-3-fluorophenol 
• 108-24-7 acetic anhydride 
• 394-41-2 3-fluoro-4-nitrophenol 
• 368833-44-7 4'-acetoxy-2'-fluoroacetanilide 
• 2369-21-3 N-(2-fluorophenyl)hydroxylamine 
• 1493-27-2 ortho-nitrofluorobenzene 
• 455-87-8 4-amino-3-fluorobenzoic acid 
• 72-89-9 acetylcoenzyme A 

Downstream Products

• 911058-19-0 N-[4-(2-adamantan-1-yl-2-oxoethoxy)-2-fluorophenyl]acetamide 
• 757251-39-1 4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide 
• 755037-03-7 regorafenib 
• 399-95-1 4-amino-3-fluorophenol 
• 1407520-32-4 C₉H₉FN₂O₄ 
• 151414-49-2 4'-methoxy-2'-fluoroacetanilide 

Relevant articles and documents

De novo biosynthesis and whole-cell catalytic production of paracetamol on a gram scale in Escherichia coli

The synthetic drug paracetamol is one of the most commonly used analgesic, antipyretic agents around the world. Global massive demand promoted its synthesis in large quantities. Chemical synthesis is the main approach for paracetamol production. However, the reaction process contributes toward environmental pollution, and the reaction conditions are harsh. Herein, we reported the construction of the paracetamol de novo biosynthetic pathway in Escherichia coli. Five enzymes from different microbial sources were heterologously expressed into E. coli to construct the APAP (1) producing strain PA1. Through protein engineering of ABH (4-aminobenzoate hydroxylase) and PANAT (arylamine N-acetyltransferase), enhancement of the host cell resistance to the substrate or final product, and utilizing synthetic protein scaffolds to optimize the metabolic flux, the engineered strain could produce 942.5 mg L-1 (6.24 mM) paracetamol in a fed-batch 5 L fermenter directly from glucose or glycerol, which circumvents the fossil fuel resource use. Moreover, we established a whole-cell cascade biocatalytic synthesis way to paracetamol and analogues. Using p-aminobenzoate as the substrate, 4.2 g L-1 (27.7 mM) paracetamol can be formed after 9 h (95% conversion rate). After metabolic engineering, enzyme molecular modification, and other optimizations, we created the biotransformation strategy to manufacture paracetamol on a gram scale. This study provides a promising green and efficient alternative to the traditional chemical manufacturing method.

Synthesis and pharmacological evaluation of piperidine (piperazine)-amide substituted derivatives as multi-target antipsychotics

We report the optimisation of a series of novel amide-piperidine (piperazine) derivatives using the multiple ligand approach with dopamine and serotonin receptors. Of the derivatives, compound 11 exhibited high affinity for the D2, 5-HT1A, and 5-HT2A receptors, but low affinity for the 5-HT2C and histamine H1 receptors and human ether-a-go-go-related gene (hERG) channels. In vivo, compound 11 reduced apomorphine-induced climbing, MK-801-induced hyperactivity and DOI-induced head twitching without observable catalepsy, even at the highest dose tested. In addition, it exhibited suppression in a CAR test. Furthermore, in a novel object recognition task, it displayed procognition properties. Therefore, compound 11 is a promising candidate multi-target antipsychotic.

Flufenoxuron intermediate 2 - fluoro - 4 - (2 - chloro - 4 - trifluoromethyl-phenoxy) aniline synthesis method

The invention discloses a flufenoxuron intermediate 2-fluoro-4-(2-chloro-4- trifluoromethyl phenoxyl) aniline synthesis method comprising the following steps: A) preparing 3-fluoro-4-acetyl amino phenol by acylation reaction of 3-fluoro-4-aminophenol and