103845-12-1

Basic information

• Product Name: Butanamide, N-[[2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl]methyl]-
• CAS NO: 103845-12-1
• Molecular Formula: C18H18ClN3O
• Molecular Weight: 327.813
• Mol File: 103845-12-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Butanamide, N-[[2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl]methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Butanamide, N-[[2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl]methyl]-(103845-12-1)
• EPA Substance Registry System: Butanamide, N-[[2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl]methyl]-(103845-12-1)

Safety Data

• Hazardous Substances Data: 103845-12-1(Hazardous Substances Data)

Upstream product

• 38427-94-0 N-(tert-butoxycarbonyl)-2-aminopyridine 
• 117459-95-7 N-(prop-2-yn-1-yl)pyridin-2-amine 
• 5857-45-4 3-methylimidazo[1,2-α]pyridine 
• 1284210-49-6 tert-butyl prop-2-yn-1-yl(pyridin-2-yl)carbamate 
• 6188-43-8 imidazo[1,2-a]pyridine-3-carbaldehyde 
• 30493-06-2 2-(4-chlorophenyl)imidazo[1,2-a]pyridine-3-carbaldehyde 
• 637-87-6 1-Chloro-4-iodobenzene 
• 536-38-9 4-chlorobenzoylmethyl bromide 
• 504-29-0 2-aminopyridine 
• 38922-74-6 2-(4-chlorophenyl)imidazolo[1,2-a]pyridine 
• 109-74-0 propyl cyanide 
• 30489-48-6 (2-(4-chlorophenyl)imidazo [1,2-a] pyridin-3-yl)methanol 
• 106-31-0 butanoic acid anhydride 
• 34164-90-4 1‐[2‐(4‐chlorophenyl)imidazo[1,2‐a]pyridin‐3‐yl]methanamine 

Downstream Products

• 103844-86-6 N-((2-(4-chlorophenyl)imidazo[1,2-a]pyridin-3-yl)methyl)-N-methylbutyramide 

Relevant articles and documents

Copper- A nd DMF-mediated switchable oxidative C-H cyanation and formylation of imidazo[1,2-: A] pyridines using ammonium iodide

The cyanation and formylation of imidazo[1,2-a]pyridines were developed under copper-mediated oxidative conditions using ammonium iodide and DMF as a nontoxic combined cyano-group source and DMF as a formylation reagent. Mechanistic studies indicate that the cyanation of imidazo[1,2-a]pyridines proceeds through a two-step sequence: Initial iodination and then cyanation. The cyanation has a broad substrate scope and high functional group tolerance, and can be safely conducted on a gram scale. A novel copper-mediated formylation using the widely available DMF as the formylation reagent and environmentally friendly molecular oxygen as the oxidant has also been developed. This protocol also provided a convenient approach for the synthesis of clinically used saripidem. This journal is

Cu(i)-catalyzed double C-H amination: synthesis of 2-iodo-imidazo[1,2-a]pyridines

An iodine/CuI mediated double oxidative C-H amination reaction has been developed for the synthesis of 2-iodo-imidazo[1,2-a]pyridines. The salient features of this methodology are mild reaction conditions and high regioselectivity. The designed compounds e.g. 2-iodo-imidazo[1,2-a]pyridines (3e) may serve as active pharmaceutical ingredients (APIs) of marketed drugs like saripidem and nicopidem. Further saripidem was synthesised by using 3e as an intermediate.

Silver-catalyzed cyclization of N-(prop-2-yn-1-yl)pyridin-2-amines

We report herein the silver-catalyzed cycloisomerization of readily available N-(prop-2-yn-1-yl)pyridine-2-amines as a new and practical method for the synthesis of differently substituted 3-methylimidazo[1,2-a]pyridines. The isomerization reactions proce