103855-44-3

Basic information

• Product Name: 1H-Indole-1-ethanamine, 3-methyl-
• CAS NO: 103855-44-3
• Molecular Formula: C11H14N2
• Molecular Weight: 174.246
• Mol File: 103855-44-3.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1H-Indole-1-ethanamine, 3-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole-1-ethanamine, 3-methyl-(103855-44-3)
• EPA Substance Registry System: 1H-Indole-1-ethanamine, 3-methyl-(103855-44-3)

Safety Data

• Hazardous Substances Data: 103855-44-3(Hazardous Substances Data)

Upstream product

• 83-34-1 3-Methylindole 
• 870-24-6 2-chloroethanamine hydrochloride 

Downstream Products

• 126718-24-9 10-methyl-1,2,3,4-tetrahydropyrazino[1,2-a]indole 
• 21689-25-8 10-methyl-1-phenyl-1,2,3,4-tetrahydropyrazino[1,2-a]indole 

Relevant articles and documents

Highly efficient one-pot synthesis of 1-substituted-1,2,3,4- tetrahydropyrazino[1,2-a]indoles

A practical and general one-pot synthesis of 1-substituted-10-methyl-1,2,3, 4-tetrahydropyrazino[1,2-a]indoles is described. The approach uses 2-(3-methyl-1H-indol-1-yl) ethylamine, benzotriazole and aldehydes in the presence of catalytic amount of acid catalysts (AlCl3, ZnCl 2, ZnBr2, p-TsOH, CH3SO3H) and proceeds in high yields via iminium cation intramolecular cyclization. The mechanism of the observed intramolecular cyclization reaction has been investigated theoretically by means of PM3 semiempirical method and results were consistent with the experimental results.

Construction of pyrrole- and indole-fused CF3-piperazine derivatives

A series of pyrrole- and indole-fused trifluoromethyl-functionalized piperazine derivatives were constructed in moderate to good yields with excellent chemoselectivities via a Pictet-Spengler reaction under mild and operationally simple conditions. The synthetic utility of this protocol was further extended by the facile preparation of indole-fused CF3-1,4-diazocane and enantioenriched CF3-piperazines via a vinylogous Pictet-Spengler reaction and an asymmetric Pictet-Spengler reaction, respectively.

Synthesis and antibacterial activity of substituted 1,2,3,4- tetrahydropyrazino [1,2-a] indoles

A series of substituted 1,2,3,4-tetrahydropyrazino [1,2-a] indole derivatives have been synthesized and tested against the Gram positive and Gram negative strains of bacteria namely Staphylococcus aureus (MTCCB 737), Salmonella typhi (MTCCB 733), Pseudomonas aeruginosa (MTCCB 741), Streptomyces thermonitrificans (MTCCB 1824) and Escherichia coli (MTCCB 1652). All synthesized compounds showed mild to moderate activity. However, compounds 4d-f were found to have potent activity against pathogenic bacteria used in the study. Their MIC ranged from 3.75 to 60 μg/disc. In vitro toxicity tests demonstrated that toxicity of 4d-f was not significantly different than that of gentamycin. However, at higher concentration (1000-4000 μg/ml) difference was highly significant.