103857-71-2

Basic information

• Product Name: 1-bromo-4-isopentylbenzene
• Synonyms: 1-bromo-4-isopentylbenzene
• CAS NO: 103857-71-2
• Molecular Weight: 227.144
• Mol File: 103857-71-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-bromo-4-isopentylbenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-bromo-4-isopentylbenzene(103857-71-2)
• EPA Substance Registry System: 1-bromo-4-isopentylbenzene(103857-71-2)

Safety Data

• Hazardous Substances Data: 103857-71-2(Hazardous Substances Data)

Upstream product

• 2049-94-7 (3-methylbutyl)benzene 
• 676-58-4 methylmagnesium chloride 
• 1122-91-4 4-bromo-benzaldehyde 
• 1591938-63-4 (Z)-1-bromo-4-(3-methylbut-1-en-1-yl)benzene 
• 3355-19-9 1-isopentyl-4-nitro-benzene 
• 1565-86-2 3-Methyl-1-phenyl-1-butanol 
• 15325-61-8 3-methyl-1-phenyl-1-butene 
• 100757-92-4 1-(p-bromophenyl)-3-methyl-1-butanol 
• 104177-72-2 4-isopentylaniline 

Downstream Products

• 586-76-5 4-Bromobenzoic acid 

Relevant articles and documents

Use of the 2-Pyridinesulfonyloxy Leaving Group for the Fast Copper-Catalyzed Coupling Reaction at Secondary Alkyl Carbons with Grignard Reagents

Investigation of the copper-catalyzed coupling reaction of 2-pyridinesulfonates with Grignard reagents revealed that reactions with catalytic Cu(OTf)2 were completed in 40 min. The results differed from those of the previous CuI-catalyzed reactions of tosylates in the presence of additives (LiOMe and TMEDA) for 12-24 h. It was shown that the preferred coordination of the leaving group to the reagents accelerated the reaction. Successful reagents were MeMgCl and other RMgX. Complete inversion was established.

Thiophenesulfonamides as endothelin receptor antagonists

The synthesis and in vitro binding affinities of a series of thiophenesulfonamides as ET(A) selective endothelin receptor antagonists is described. The most potent inhibitor displayed an IC50 of 43 nM and 3 μM to ET(A) and ET(B) receptors, respectively.