103858-52-2 Usage
General Description
4-Bromoindole-2-carboxylic acid ethyl ester is a chemical compound with the molecular formula C11H10BrNO2. It is a derivative of indole, a heterocyclic aromatic organic compound. This chemical is commonly used in the development and synthesis of pharmaceuticals and agrochemicals. It is known for its potential antiviral and anti-inflammatory properties, and has been studied for its potential applications in drug discovery and development. 4-Bromoindole-2-carboxylic acid ethyl ester is a versatile compound with a wide range of potential uses in various fields of chemistry and pharmaceutical research.
Check Digit Verification of cas no
The CAS Registry Mumber 103858-52-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,3,8,5 and 8 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 103858-52:
(8*1)+(7*0)+(6*3)+(5*8)+(4*5)+(3*8)+(2*5)+(1*2)=122
122 % 10 = 2
So 103858-52-2 is a valid CAS Registry Number.
InChI:InChI=1/C11H10BrNO2/c1-2-15-11(14)10-6-7-8(12)4-3-5-9(7)13-10/h3-6,13H,2H2,1H3
103858-52-2Relevant articles and documents
The first potent and selective non-imidazole human histamine H4 receptor antagonists
Jablonowski, Jill A.,Grice, Cheryl A.,Chai, Wenying,Dvorak, Curt A.,Venable, Jennifer D.,Kwok, Annette K.,Ly, Kiev S.,Wei, Jianmei,Baker, Sherry M.,Desai, Pragnya J.,Jiang, Wen,Wilson, Sandy J.,Thurmond, Robin L.,Karlsson, Lars,Edwards, James P.,Lovenberg, Timothy W.,Carruthers, Nicholas I.
, p. 3957 - 3960 (2003)
Following the discovery of the human histamine H4 receptor, a high throughput screen of our corporate compound collection identified compound 6 as a potential lead. Investigation of the SAR resulted in the discovery of novel compounds 10e and 10l, which are the first potent and selective histamine H4 receptor antagonists to be described.
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Hemetsberger et al.
, p. 161,164-165 (1970)
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7-NONSUBSTITUTED INDOLE MCL-1 INHIBITORS
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Page/Page column 102-103, (2008/12/08)
Compounds of formula (I) which inhibit the activity of anti-apoptotic Mcl-1 protein, compositins containing the compounds, and methods of treating diseases involving overexpressed or unregulated Mcl-1 protein are disclosed.
