103859-86-5

Basic information

• Product Name: 4-(4'-Methoxyphenyl)-2-pyrrolidinone
• Synonyms: 4-(4'-Methoxyphenyl)-2-pyrrolidinone;4-(4-methoxyphenyl)pyrrolidin-2-one
• CAS NO: 103859-86-5
• Molecular Formula: C₁₁H₁₃NO₂
• Molecular Weight: 191.23
• Mol File: 103859-86-5.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(4'-Methoxyphenyl)-2-pyrrolidinone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4'-Methoxyphenyl)-2-pyrrolidinone(103859-86-5)
• EPA Substance Registry System: 4-(4'-Methoxyphenyl)-2-pyrrolidinone(103859-86-5)

Safety Data

• Hazardous Substances Data: 103859-86-5(Hazardous Substances Data)

Usage

General Description

4-(4'-Methoxyphenyl)-2-pyrrolidinone, also known as 4-methoxyphenyl-2-pyrrolidinone, is a chemical compound with the molecular formula C11H13NO2. It is a white to off-white solid with a melting point of 74-77°C. 4-(4'-Methoxyphenyl)-2-pyrrolidinone is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and various other organic compounds. It is also used as a building block in the production of other chemical compounds due to its versatility and reactivity. Additionally, 4-(4'-Methoxyphenyl)-2-pyrrolidinone exhibits potential as a reactant in organic chemical reactions and has shown promise in various research applications.

Upstream product

• 24393-56-4 ethyl p-methoxycinnamate 
• 745060-01-9 ethyl 3-(4-methoxyphenyl)-4-nitrobutanoate 
• 830-09-1 3-(4'-methoxyphenyl)propenoic acid 
• 832-01-9 methyl p-methoxycinnamate 
• 100373-19-1 4-(4-methoxy-phenyl)-2-oxo-pyrrolidine-3-carboxylic acid methyl ester 
• 24314-15-6 4-amino-3-(4-methoxyphenyl)butanoic acid 
• 62836-52-6 4-(4-methoxy-phenyl)-2-oxo-pyrrolidine-3-carboxylic acid 

Downstream Products

• 1019648-69-1 N-(4-(4-(4-methoxyphenyl)-2-oxopyrrolidin-1-yl)pyridin-2-yl)-N'-(pyridin-2-ylmethyl)urea 
• 1019648-68-0 bis(2,2,2-trichloroethyl)(4-(4-(4-methoxyphenyl)-2-oxopyrrolidin-1-yl)pyridin-2-yl)imidodicarbonate 
• 100372-85-8 1-acetyl-4-(4-methoxy-phenyl)-pyrrolidin-2-one 
• 127345-89-5 4-(3-iodo-4-methoxyphenyl)pyrrolidin-2-one 

Relevant articles and documents

Catalytic Intermolecular Carboamination of Unactivated Alkenes via Directed Aminopalladation

An intermolecular 1,2-carboamination of unactivated alkenes proceeding via a Pd(II)/Pd(IV) catalytic cycle has been developed. To realize this transformation, a cleavable bidentate directing group is used to control the regioselectivity of aminopalladation and stabilize the resulting organopalladium(II) intermediate, such that oxidative addition to a carbon electrophile outcompetes potential β-hydride elimination. Under the optimized reaction conditions, a broad range of nitrogen nucleophiles and carbon electrophiles are compatible coupling partners in this reaction, affording moderate to high yields. The products of this reaction can be easily converted to free ?3-amino acids and ?3-lactams, both of which are common structural motifs found in drug molecules and bioactive compounds. Reaction kinetics and DFT calculations shed light on the mechanism of the reaction and explain empirically observed reactivity trends.

From paracetamol to rolipram and derivatives: Application of deacetylation-diazotation sequences and palladium-catalyzed matsuda-heck reaction

A six-step synthesis of the antidepressant rolipram from the popular analgetic 4-acetamidophenol (paracetamol) is described. The steps include oxidative functionalization of the aromatic core, diazonium salt formation via deacetylation-diazotation, Matsuda-Heck reaction, conjugate addition of nitromethane, and hydrogenative cyclization. Georg Thieme Verlag Stuttgart · New York.