1039307-95-3

Basic information

• Product Name: (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-aMino-2-Methylpentanoic acid
• Synonyms: (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-aMino-2-Methylpentanoic acid
• CAS NO: 1039307-95-3
• Molecular Weight: 283.37
• EINECS: -0
• Mol File: 1039307-95-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-aMino-2-Methylpentanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-aMino-2-Methylpentanoic acid(1039307-95-3)
• EPA Substance Registry System: (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-aMino-2-Methylpentanoic acid(1039307-95-3)

Safety Data

• Hazardous Substances Data: 1039307-95-3(Hazardous Substances Data)

Usage

General Description

The chemical compound "(2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-aMino-2-Methylpentanoic acid" is a chiral amino acid derivative with a molecular formula of C18H21NO2. It is an organic compound with two stereocenters and a biphenyl group attached to the α-amino group. (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-aMino-2-Methylpentanoic acid is not a naturally occurring amino acid, but rather a synthetic derivative that can be used in pharmaceutical research and development. It may have potential applications in medicinal chemistry, such as in the development of new drugs targeting specific biological pathways or processes. The compound's structural and stereochemical features make it an interesting target for further investigation and potential use in drug design.

Upstream product

• 31603-77-7 4-biphenylacetonitrile 
• 5728-52-9 (4-biphenylyl)acetic acid 

Downstream Products

• 752174-62-2 (2R,4S)-4-amino-5-biphenyl-4-yl-2-methylpentanoic acid ethyl ester 
• 149690-12-0 (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-amino-2-methylpentanoic acid ethyl ester hydrochloride 
• 149709-62-6 α-ethyl (αR,γS)-γ-<(3-carboxy-1-oxopropyl)amino>-α-methyl<1,1'-biphenyl>-4-pentanoate 

Relevant articles and documents

Preparation method of neprilysin inhibitor intermediate

The invention discloses a preparation method for an enkephalinase inhibitor intermediate. According to the preparation method, a target compound with a formula I as described in the specification is prepared by using a compound as shown in a formula IV which is described in the specification as an initial material through a reaction with few steps, wherein the compound with the formula I can be used for preparation of an enkephalinase inhibitor drug namely Sacubtril. In the formula I and the formula IV, R is selected from the group consisting of H, methyl, ethyl or other lower alkyl.

SACUBITRIL INTERMEDIATE AND PREPARATION METHOD THEREOF

The present invention relates to a sacubitril intermediate and a preparation method thereof. The sacubitril intermediate disclosed herein can be prepared by a deprotection reaction of a compound. In addition, the intermediate can be used as a raw material to synthesize sacubitril. The method disclosed herein has advantages of easily obtained raw materials, simple preparation process, low cost, environment friendly, and etc., which is very suitable for industrial production.

Sacubitril intermediate and preparation method thereof

The invention relates to a sacubitril intermediate and a preparation method thereof, the sacubitril intermediate is a compound shown as formula (04), and the sacubitril intermediate is prepared by deprotection reaction of a compound shown as formula (03). Further, the invention also provides the preparation method of the compound shown as the formula (04) as the intermediate. The method has the advantages of easy availability of raw materials, simple process, economy and environmental protection, and the like, and is very suitable for industrial production.