103934-77-6

Basic information

• Product Name: trans-1,3-dihydro-1-methoxy-3-phenylisobenzofuran
• CAS NO: 103934-77-6
• Molecular Weight: 226.275
• Mol File: 103934-77-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: trans-1,3-dihydro-1-methoxy-3-phenylisobenzofuran(CAS DataBase Reference)
• NIST Chemistry Reference: trans-1,3-dihydro-1-methoxy-3-phenylisobenzofuran(103934-77-6)
• EPA Substance Registry System: trans-1,3-dihydro-1-methoxy-3-phenylisobenzofuran(103934-77-6)

Safety Data

• Hazardous Substances Data: 103934-77-6(Hazardous Substances Data)

Upstream product

• 6630-33-7 ortho-bromobenzaldehyde 
• 35849-09-3 o-bromobenzaldehyde dimethyl acetal 
• 67-56-1 methanol 
• 5398-11-8 3-phenylphthalide 
• 1478-41-7 diethoxycarbonium fluoroborate 

Relevant articles and documents

Synthesis of oxa-bridged analogues of farnesyltransferase inhibitor RPR 115135

Two synthetic routes to new oxygen-bridged analogues of farnesyltransferase inhibitors are described that follow either a [3 + 2]/[4 + 2] or a [4 + 2]/[3 + 2] sequence of reactions. The first approach has been achieved by reacting the in situ generated phenylisobenzofuran (PIBF) 4 with pyrroline 5a and has led stereoselectively to racemic 18, which was transformed in a few steps into the target molecule 2. The second pathway relies on a key intermediate 6, obtained either by condensation of PIBF with methyl acrylate, followed by a deprotonation/selenation and an oxidation/elimination sequence, or by cycloaddition between PIBF and α-phenylselenoacrylate 11, followed by the same oxidation/elimination sequence. The reaction of 6 with amino dipole 7 gives diastereoselective access to pyrrolidine 25, a precursor of the second target 3, an epimer of 2.