1039559-03-9

Basic information

• Product Name: (Z)-2-(5-(4-(benzyloxy)benzylidene)-2,4-dioxothiazolidin-3-yl)acetic acid
• Synonyms: (Z)-2-(5-(4-(benzyloxy)benzylidene)-2,4-dioxothiazolidin-3-yl)acetic acid
• CAS NO: 1039559-03-9
• Molecular Weight: 369.398
• Mol File: 1039559-03-9.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: (Z)-2-(5-(4-(benzyloxy)benzylidene)-2,4-dioxothiazolidin-3-yl)acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-2-(5-(4-(benzyloxy)benzylidene)-2,4-dioxothiazolidin-3-yl)acetic acid(1039559-03-9)
• EPA Substance Registry System: (Z)-2-(5-(4-(benzyloxy)benzylidene)-2,4-dioxothiazolidin-3-yl)acetic acid(1039559-03-9)

Safety Data

• Hazardous Substances Data: 1039559-03-9(Hazardous Substances Data)

Upstream product

• 39137-34-3 (2,4-thiazolidinedion-3-yl)acetic acid ethyl ester 
• 4397-53-9 p-benzyloxybenzaldehyde 
• 18345-22-7 (2,4-dioxothiazolidin-3-yl)acetic acid methyl ester 
• 31061-24-2 2-(2,4-dioxo-1,3-thiazolidin-3-yl)acetic acid 

Downstream Products

• 1233344-37-0 C₁₉H₁₄ClNO₄S 

Relevant articles and documents

Synthesis and structure-activity relationship studies of 2,4-thiazolidinediones and analogous heterocycles as inhibitors of dihydrodipicolinate synthase

Dihydrodipicolinate synthase (DHDPS), responsible for the first committed step of the diaminopimelate pathway for lysine biosynthesis, has become an attractive target for the development of new antibacterial and herbicidal agents. Herein, we report the di

5-Arylidene-4-thiazolidinone derivatives active as antidegenerative agents on human chondrocyte cultures

5-Arylidene-2-oxo-4-thiazolidinones and 2-phenylimino analogues were evaluated for their antidegenerative activity on human chondrocyte cultures stimulated by IL-1β and for their inhibitory capability against matrix metalloproteinase- 13. Our results indicated that 5-arylidene-4-thiazolidinone derivatives 1-9 exhibit antidegenerative activity and could block multiple cartilage destruction during the osteoarthritic process. Out of the selected compounds, (5-arylidene- 2,4-dioxothiazolidin-3-yl)acetic acids 7-9 showed significant effectiveness in reducing NO release and restoring normal levels of GAGs in chondrocytes treated with IL-1β. Moreover, benzoic acids 1, 5 and 6 proved to be effective MMP-13 inhibitors and were able to restore normal levels of GAGs.

Synthesis, induced-fit docking investigations, and in vitro aldose reductase inhibitory activity of non-carboxylic acid containing 2,4-thiazolidinedione derivatives

In continuation of our studies, we here report a series of non-carboxylic acid containing 2,4-thiazolidinedione derivatives, analogues of previously synthesized carboxylic acids which we had found to be very active in vitro aldose reductase (ALR2) inhibit