1039775-38-6

Basic information

• Product Name: 2-Methoxy-6-p-tolylpyridine
• Synonyms: 2-Methoxy-6-p-tolylpyridine
• CAS NO: 1039775-38-6
• Molecular Formula: C₁₃H₁₃NO
• Molecular Weight: 199.24842
• Mol File: 1039775-38-6.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-Methoxy-6-p-tolylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methoxy-6-p-tolylpyridine(1039775-38-6)
• EPA Substance Registry System: 2-Methoxy-6-p-tolylpyridine(1039775-38-6)

Safety Data

• Hazardous Substances Data: 1039775-38-6(Hazardous Substances Data)

Usage

General Description

2-Methoxy-6-p-tolylpyridine is a chemical compound with the molecular formula C13H13NO and a molecular weight of 199.25 g/mol. It is also referred to as 2-Methoxy-6-(p-tolyl)pyridine and is commonly used as an intermediate in organic synthesis and pharmaceutical research. 2-Methoxy-6-p-tolylpyridine is a pyridine derivative, and its structure consists of a pyridine ring with a methoxy group attached to the 2 position and a p-tolyl group attached to the 6 position. It is a white to off-white solid that is sparingly soluble in water but soluble in common organic solvents. 2-Methoxy-6-p-tolylpyridine is widely used in the manufacturing of pharmaceutical drugs, agrochemicals, and other organic compounds.

Upstream product

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Relevant articles and documents

Sulfonated N-heterocyclic carbenes for Pd-catalyzed sonogashira and suzuki-miyaura coupling in aqueous solvents

The reactions of the N, N-diarylimidazolium and N, N-diarylimidazolinium salts with chlorosulfonic acid result in the formation of the respective disulfonated N-heterocyclic carbene (NHC) precursors in reasonable yields (46-77%). Water-soluble palladium catalyst complexes, in situ obtained from the respective sulfonated imidazolinium salt, sodium tetrachloropalladate (Na 2PdCl4) and potassium hydroxide (KOH) in water, were successfully applied in the copper-free Sonogashira coupling reaction in isopropyl alcohol/water mixtures using 0.2 mol% catalyst loading. The preformed (disulfonatedNHC)PdCl(cinnamyl) complex was used in aqueous Suzuki-Miyaura reactions at 0.1 mol% catalyst loading. The coupling protocol reported here is very useful for Sonogashira reactions of N- and 5-heterocyclic aryl bromides and chlorides with aryl- and alkylacetylenes.

Anthranilamide (aam)-substituted arylboranes in direct carbon-carbon bond-forming reactions

Anthranilamide (aam)-substituted arylboranes, which were reported to serve as masked boranes in the Suzuki-Miyaura coupling, have been found to be directly cross-coupled just by use of an aqueous medium. The excellent stability of 2-pyridyl-B(aam) toward protodeborylation allowed their smooth cross-coupling.

Kumada coupling of aryl, heteroaryl, and vinyl chlorides catalyzed by amido pincer nickel complexes

A series of amido pincer complexes of nickel were examined for their catalysis in the Kumada cross-coupling reaction. The P,N,O-pincer nickel complexes tested are active catalysts for the cross-coupling of aryl, heteroaryl, and vinyl chlorides with aryl Grignard reagents. The reactions can proceed at room temperature and tolerate functional groups in aryl chlorides with the aid of LiCl and ZnCl2 additives (Figure presented).