103986-96-5

Basic information

• Product Name: methyl (E)-3-(4′-methoxy-2′-nitrophenyl)acrylate
• Synonyms: methyl (E)-3-(4′-methoxy-2′-nitrophenyl)acrylate
• CAS NO: 103986-96-5
• Molecular Weight: 237.212
• Mol File: 103986-96-5.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: methyl (E)-3-(4′-methoxy-2′-nitrophenyl)acrylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (E)-3-(4′-methoxy-2′-nitrophenyl)acrylate(103986-96-5)
• EPA Substance Registry System: methyl (E)-3-(4′-methoxy-2′-nitrophenyl)acrylate(103986-96-5)

Safety Data

• Hazardous Substances Data: 103986-96-5(Hazardous Substances Data)

Upstream product

• 292638-85-8 acrylic acid methyl ester 
• 96-96-8 4-methoxy-2-nitroaniline 
• 22996-21-0 4-methoxy-2-nitro-benzaldehyde 
• 17484-36-5 4-Methyl-3-nitroanisole 
• 33844-21-2 2-nitro-4-methoxybenzoic acid 
• 89337-61-1 tert-butyl((1-methoxyprop-1-en-1-yl)oxy)dimethylsilane 
• 67-56-1 methanol 
• 90945-66-7 3-(4-methoxy-2-nitrophenyl)acrylic acid 
• 5344-78-5 4-bromo-3-nitroanizole 
• 58755-70-7 1-iodo-4-methoxy-2-nitrobenzene 

Downstream Products

• 1050514-06-1 5-methoxy-2-[3-(methylthio)propyl]aniline 
• 1050503-76-8 3-(4-methoxy-2-nitrophenyl)propan-1-ol 
• 1050513-78-4 3-(4-methoxy-2-nitrophenyl)-N,N-dimethylpropan-1-amine 
• 1050513-77-3 C₁₁H₁₅NO₆S 
• 1050514-07-2 tert-butyl 5-methoxy-2-[3-(methylthio)propyl]phenylcarbamate 
• 1050514-08-3 tert-butyl 5-methoxy-2-[3-(methylsulfonyl)propyl]phenylcarbamate 
• 1050514-09-4 5-methoxy-2-[3-(methylsulfonyl)propyl]aniline hydrochloride 
• 23981-26-2 7-methoxyquinolin-2(1H)-one 
• 1224927-76-7 2-[6′-(4′′-chlorophenyl)-7′-methoxy-3′,4′-dihydro-1H-quinolin-2′-one-1′-yl]acetic acid 

Relevant articles and documents

Synthesis and evaluation of 2-carboxy indole derivatives as potent and selective anti-leukemic agents

Despite the success achieved in the treatment of acute lymphoblastic leukemia (ALL), the search for new drugs featuring selectivity against leukemia cells and effectiveness to prevent relapsed ALL is still highly desirable. Here, we described the synthesi

Palladium Nanoparticles Supported on Sulfonic Acid Functionalized Silica as Trifunctional Heterogeneous Catalysts for Heck and Suzuki Reactions

The arylation of acrylates and boronic acids with anilines, through in situ generated aryl diazonium salts, was successfully achieved by using trifunctional heterogeneous catalysts bearing Br?nsted acid and metal active sites. The trifunctional materials were prepared by adsorption of palladium nanoparticles, generated by reduction of a solution of Pd(OAc)2 onto a commercially available sulfonic acid functionalized silica. These new trifunctional catalysts act as a 1) proton donor for the diazotization step, 2) counterion for the diazonium salt, and 3) Pd source for the coupling step. This unprecedented strategy, features mild and safe conditions as hazardous aryl diazonium salts are generated in situ and only produces environmentally friendly byproducts such as tBuOH, H2O, and N2.

Continuous-flow Heck - Matsuda reaction: Homogeneous versus heterogeneous palladium catalysts

This study describes extensive investigations of the Heck-Matsuda reaction carried out by continuous-flow chemistry between aryl diazonium salts generated in situ and methyl acrylate. Our optimized procedures enable sequential aniline diazotization/palladium-catalyzed Heck-Matsuda reaction using either Pd(OAc)2 or PdEnCat 30 as respectively a homogeneous or a heterogeneous source of palladium. This safe chemistry that does not require the handling of hazardous aryl diazonium salts involves inexpensive reagents and solvents, under ligand- and base-free conditions. (Chemical Equation Presented)