103989-12-4

Basic information

• Product Name: 3-(4-acetylphenyl)-1,3-oxazolidin-2-one
• Synonyms: 3-(4-acetylphenyl)-1,3-oxazolidin-2-one
• CAS NO: 103989-12-4
• Molecular Formula: C₁₁H₁₁NO₃
• Molecular Weight: 205.20994
• Mol File: 103989-12-4.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(4-acetylphenyl)-1,3-oxazolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-acetylphenyl)-1,3-oxazolidin-2-one(103989-12-4)
• EPA Substance Registry System: 3-(4-acetylphenyl)-1,3-oxazolidin-2-one(103989-12-4)

Safety Data

• Hazardous Substances Data: 103989-12-4(Hazardous Substances Data)

Usage

General Description

3-(4-acetylphenyl)-1,3-oxazolidin-2-one is a chemical compound with the molecular formula C11H11NO3. It is commonly referred to as (S)-4-acetylphenylglycine, and it is a white solid that is insoluble in water. 3-(4-acetylphenyl)-1,3-oxazolidin-2-one is often used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. It has been shown to possess antibacterial and antifungal properties, making it a potential candidate for the development of new drugs. Additionally, its unique molecular structure and reactivity make it a valuable building block for the creation of diverse chemical compounds.

Upstream product

• 124-38-9 carbon dioxide 
• 99-92-3 p-aminobenzophenone 
• 107-06-2 1,2-dichloro-ethane 
• 96-49-1 [1,3]-dioxolan-2-one 
• 5602-93-7 ethyl (2-hydroxyethyl)carbamate 
• 13329-40-3 4-Iodoacetophenone 
• 497-25-6 dimethylenecyclourethane 
• 99-90-1 para-bromoacetophenone 
• 99859-99-1 (4-acetyl-phenyl)-carbamic acid-(2-chloro-ethyl ester) 
• 109-89-7 diethylamine 
• 110-89-4 piperidine 

Relevant articles and documents

Copper-Catalyzed One-Pot Synthesis of N -Aryl Oxazolidinones from Amino Alcohol Carbamates

An efficient sequential intramolecular cyclization of amino alcohol carbamates followed by Cu-catalyzed cross-coupling with aryl iodides under mild conditions has been developed. The reaction occurred in good yields and tolerated aryl iodides containing functionalities such as nitriles, ketones, ethers, and halogens. Heteroaryl iodides and substituted amino alcohol carbamates were also well tolerated.

Synthesis of Oxazolidinones and Derivatives through Three-Component Fixation of Carbon Dioxide

An effective three-component fixation of atmospheric CO2 with readily available 1,2-dichloroethane and aromatic amine toward oxazolidinones catalyzed by in situ NHC was developed. The reaction occurred in good to excellent yields with good gene

CuI/N,N-dimethylglycine-catalyzed synthesis of N-aryloxazolidinones from aryl bromides

CuI/N,N-dimethylglycine catalyzed coupling of aryl bromides with substituted oxazolidinones took place at 120 °C in DMF, affording the corresponding N-arylation products with good to excellent yields. A number of functional groups, such as ketone, nitrile, nitro, methoxy, and hydroxyl were tolerated under these conditions, thereby allowing diversity synthesis of N-aryloxazolidinones.