1040048-65-4

Basic information

• Product Name: N-(4-phenylbutan-2-yl)octan-1-amine
• Synonyms: N-(4-phenylbutan-2-yl)octan-1-amine
• CAS NO: 1040048-65-4
• Molecular Weight: 261.451
• Mol File: 1040048-65-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-(4-phenylbutan-2-yl)octan-1-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-phenylbutan-2-yl)octan-1-amine(1040048-65-4)
• EPA Substance Registry System: N-(4-phenylbutan-2-yl)octan-1-amine(1040048-65-4)

Safety Data

• Hazardous Substances Data: 1040048-65-4(Hazardous Substances Data)

Upstream product

• 111-86-4 n-Octylamine 
• 2550-26-7 4-Phenyl-2-butanone 

Relevant articles and documents

Fast reductive amination by transfer hydrogenation "on water"

Reductive amination of various ketones and aldehydes by transfer hydrogenation under aqueous conditions has been developed, by using cyclometallated iridium complexes as catalysts and formate as hydrogen source. The pH value of the solution is shown to be critical for a high catalytic chemoselectivity and activity, with the best pH value being 4.8. In comparison with that in organic solvents, the reductive amination in an aqueous phase is faster, and the molar ratio of the substrate to the catalyst (S/C) can be set as high as 1×105, the highest S/C value ever reported in reductive amination reactions. The catalyst is easy to access and the reaction is operationally simple, allowing a wide range of ketones and aldehydes to react with various amines in high yields. The protocol provides a practical and environmental friendly new method for the synthesis of amine compounds. Greener amine synthesis: A versatile reductive amination protocol has been developed. By using an iridium catalyst in water, a broad range of ketones and aldehydes react with amines to afford various new amines in good yields (see scheme), with molar ratios of the substrate to the catalyst (S/C) as high as 1×10 5. The pH of the reaction solution plays a key role, regulating both the catalytic activity and the selectivity. Copyright

CATALYST COMPOUNDS

The present invention relates to an iridium-based catalyst compound for hydrogenating reducible moieties, especially imines and iminiums, the catalyst compounds being defined by the formulas: where ring B is either itself polycyclic, or ring B together with R is polycyclic. The catalysts of the invention are particularly effective in reductive amination procedures 10 which involve the in situ generation of the imine or iminium under reductive hydrogenative conditions.