1040272-02-3

Basic information

• Product Name: (R)-3-(benzyloxycarbonyl)-3-hydroxyhex-5-enoic acid
• Synonyms: (R)-3-(benzyloxycarbonyl)-3-hydroxyhex-5-enoic acid
• CAS NO: 1040272-02-3
• Molecular Weight: 264.278
• Mol File: 1040272-02-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (R)-3-(benzyloxycarbonyl)-3-hydroxyhex-5-enoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-(benzyloxycarbonyl)-3-hydroxyhex-5-enoic acid(1040272-02-3)
• EPA Substance Registry System: (R)-3-(benzyloxycarbonyl)-3-hydroxyhex-5-enoic acid(1040272-02-3)

Safety Data

• Hazardous Substances Data: 1040272-02-3(Hazardous Substances Data)

Upstream product

• 92572-56-0 2-((2R, 4R)-2-tert-butyl-4-allyl-5-oxo-1,3-dioxolan-4-yl)acetic acid 
• 100-51-6 benzyl alcohol 

Downstream Products

• 1040272-04-5 (R)-benzyl 2-allyl-4-oxooxetane-2-carboxylate 
• 1040272-07-8 C₂₆H₂₄O₈ 

Relevant articles and documents

Synthesis of antiproliferative cephalotaxus esters and their evaluation against several human hematopoietic and solid tumor cell lines: Uncovering differential susceptibilities to multidrug resistance

Deoxyharringtonine (2), homoharringtonine (3), homodeoxyharringtonine (4), and anhydroharringtonine (5) are reported to be among the most potent members of the antileukemia alkaloids isolated from the Cephalotaxus genus. Convergent syntheses of these four natural products are described, each involving novel synthetic methods and strategies. These syntheses enabled evaluation of several advanced natural and non-natural compounds against an array of human hematopoietic and solid tumor cells. Potent cytotoxicity was observed in several cell lines previously not challenged with these alkaloids. Variations in the structure of the ester chain within this family of alkaloids confer differing activity profiles against vincristine-resistant HL-60/RV+, signalling new avenues for molecular design of these natural products to combat multi-drug resistance.