104035-18-9

Basic information

• Product Name: 2-amino-N-2H-1,2,4-triazol-3-ylbenzamide
• Synonyms: 2-amino-N-2H-1,2,4-triazol-3-ylbenzamide
• CAS NO: 104035-18-9
• Molecular Weight: 203.203
• Mol File: 104035-18-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-amino-N-2H-1,2,4-triazol-3-ylbenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-amino-N-2H-1,2,4-triazol-3-ylbenzamide(104035-18-9)
• EPA Substance Registry System: 2-amino-N-2H-1,2,4-triazol-3-ylbenzamide(104035-18-9)

Safety Data

• Hazardous Substances Data: 104035-18-9(Hazardous Substances Data)

Upstream product

• 610-14-0 2-nitrobenzyl chloride 
• 104035-16-7 3-amino-2-(2-nitrobenzoyl)-2H-1,2,4-triazole 
• 104035-17-8 2-nitro-N-2H-1,2,4-triazol-3-ylbenzamide 
• 104035-17-8 2-nitro-benzoic acid-(1H-[1,2,4]triazol-3-ylamide) 
• 61-82-5 3⁽⁵⁾-amino-1,2,4-triazole 
• 118-48-9 isatoic anhydride 

Relevant articles and documents

3-(1H-Tetrazol-5-yl)-4(3H)-quinazolinone Sodium Salt (MDL 427): A New Antiallergic Agent

Syntheses for 3-(1H-tetrazol-5-yl)-4(3H)-quinazolinone sodium salt monohydrate (9; MDL 427) and the related formamido compound, 2-(formylamino)-N-1H-tetrazol-5-ylbenzamide (10), are described.Both compounds are active in the rat passive cutaneous anaphylaxis and passive peritoneal anaphylaxis tests.A 94:6 equilibrium mixture of 9 and ionized 10, respectively, forms in aqueous buffer systems at a pH-dependent rate.In addition, analogues of 3-(1H-tetrazol-5-yl)-4(3H)-quinazolinone (8) bearing substituents on the benzene ring, substituents at the 2-position, and heteroaryl groups at the 3-position other than tetrazole were prepared.These analogue sets demonstrated that an accessible electrophilic center and an acidic functionality were requirements for good antiallergic activity.