1040363-82-3

Basic information

• Product Name: (1R,2R)-2-(1'-hydroxy-1'-methyl-ethyl)-1-cyclohexanol
• CAS NO: 1040363-82-3
• Molecular Weight: 158.241
• Mol File: 1040363-82-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1R,2R)-2-(1'-hydroxy-1'-methyl-ethyl)-1-cyclohexanol(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2R)-2-(1'-hydroxy-1'-methyl-ethyl)-1-cyclohexanol(1040363-82-3)
• EPA Substance Registry System: (1R,2R)-2-(1'-hydroxy-1'-methyl-ethyl)-1-cyclohexanol(1040363-82-3)

Safety Data

• Hazardous Substances Data: 1040363-82-3(Hazardous Substances Data)

Upstream product

• 59587-09-6 (R)-2-acetylamino-3-mercapto-propionic acid ethyl ester 
• 42953-13-9 1-(1-hydroperoxy-1-methylethyl)cyclohexene 

Relevant articles and documents

Identification of radical species derived from allergenic 15-hydroperoxyabietic acid and insights into the behaviour of cyclic tertiary allylic hydroperoxides in Fe(II)/Fe(III) systems

To understand the skin sensitization mechanism of 15-hydroperoxyabietic acid, the major allergen in colophony, we first examined the formation of potential reactive radicals derived from its reaction with light, heat and TPP-Fe3+. Trapping with 1,1,3,3-tetramethylisoindolin-2-yloxyl nitroxide confirmed the?formation of carbon-centred radicals derived from allyloxyl/allylperoxyl radicals as a consequence of the hydroperoxide scission. Particular interest was further given to the reactivity with Fe(II)/Fe(III) due to?the biological importance of haem containing enzymes. Using a monocyclic 15-hydroperoxyabietic acid-like compound as a model of allergenic allylic hydroperoxides, we evidenced, by the ESR spin-trapping technique, the competition between carbon and oxygen-centred radicals formed in the presence of Fe(II)/Fe(III) in organic/aqueous media. We complemented the study by showing the possibility of formation, via a radical mechanism induced by ferric chloride, of an adduct between the allylic hydroperoxide and N-acetyl-cysteine ethyl ester. The results gave new knowledge on the possible generation of highly reactive radicals that could lead to the formation of antigenic structures.