1040384-56-2

Basic information

• Product Name: C₆H₅C₃H₃NOC(CH₃)2OP(OC₆H₂(C(CH₃)3)2)2
• Synonyms: C₆H₅C₃H₃NOC(CH₃)2OP(OC₆H₂(C(CH₃)3)2)2
• CAS NO: 1040384-56-2
• Molecular Weight: 643.847
• Mol File: 1040384-56-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₆H₅C₃H₃NOC(CH₃)2OP(OC₆H₂(C(CH₃)3)2)2(CAS DataBase Reference)
• NIST Chemistry Reference: C₆H₅C₃H₃NOC(CH₃)2OP(OC₆H₂(C(CH₃)3)2)2(1040384-56-2)
• EPA Substance Registry System: C₆H₅C₃H₃NOC(CH₃)2OP(OC₆H₂(C(CH₃)3)2)2(1040384-56-2)

Safety Data

• Hazardous Substances Data: 1040384-56-2(Hazardous Substances Data)

Upstream product

• 1040384-29-9 C₁₂H₁₅NO₂ 
• 71941-98-5 3,3',5,5'-tetra-tert-butyl-1,1'-biphenyl-2,2'-diyl phosphorochloridite 

Relevant articles and documents

Modular phosphite-oxazoline/oxazine ligand library for asymmetrie Pd-catalyzed allylic substitution reactions: scope and limitations - origin of enantioselectivity

A library of phosphite-oxazoline/oxazine ligands L1-L15a-h has been synthesized and screened in the Pd-catalyzed allylic substitution reactions of several substrate types. These series of ligands can be prepared efficiently from easily accessible hydroxyl amino acid derivatives. Their modular nature enables the substituents/configurations in the oxazoline/oxazine moiety, alkyl backbone chain and in the biaryl phosphite moiety to be easily and systematically varied. By carefully selecting the ligand components, therefore, high regio- and enantioselectivities (ee values up to 99%) and good activities have been achieved in a broad range of mono- and disubstituted linear hindered and unhindered liner and cyclic substrates. The NMR studies on the Pd-π-allyl intermediates provide a deeper understanding about the effect of the ligand parameters on the origin of enantioselectivity. It also indicates that the nucleophilic attack takes place predominantly at the allylic terminal carbon atom located trans to the phosphite moiety.