104057-63-8 Usage
Description
(S)-2-[2,2-DIMETHYL-PROP-(E)-YLIDENEAMINO]-PROPIONATE SODIUM, also known as S-AMPA, is a synthetic analog of the neurotransmitter glutamate. It is a potent and selective AMPA receptor agonist that is commonly used in research to study the mechanisms of excitatory neurotransmission in the central nervous system. S-AMPA has been shown to enhance synaptic transmission, leading to increased neuronal excitability. Its sodium salt form allows for improved solubility and stability, making it a valuable tool in neuroscience research and drug development.
Uses
Used in Neuroscience Research:
S-AMPA is used as a research tool for studying the mechanisms of excitatory neurotransmission in the central nervous system. It helps researchers understand the role of AMPA receptors in various neurological processes and disorders.
Used in Drug Development:
S-AMPA is used as a potential therapeutic agent in the treatment of neurodegenerative diseases and cognitive disorders. Its ability to enhance synaptic transmission and increase neuronal excitability makes it a promising candidate for developing new treatments for conditions such as Alzheimer's disease, Parkinson's disease, and other cognitive impairments.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, S-AMPA is used as a starting material or intermediate in the synthesis of other AMPA receptor modulators. These modulators can be developed into drugs targeting various neurological and psychiatric conditions.
Used in Academic Research:
S-AMPA is used in academic research institutions to study the effects of AMPA receptor activation on learning, memory, and synaptic plasticity. This helps in understanding the underlying mechanisms of cognitive functions and the development of related therapeutic strategies.
Check Digit Verification of cas no
The CAS Registry Mumber 104057-63-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,4,0,5 and 7 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 104057-63:
(8*1)+(7*0)+(6*4)+(5*0)+(4*5)+(3*7)+(2*6)+(1*3)=88
88 % 10 = 8
So 104057-63-8 is a valid CAS Registry Number.
104057-63-8Relevant articles and documents
Synthese enantioselective d'α-aryl amino acides: subtitution nucleophile aromatique sur le fluorobenzene chrome tricarbonyle d'enolates chiraux
Chaari, M.,Jenhi, A.,Lavergne, J.-P.,Viallefont, Ph.
, p. C10 - C13 (2007/10/02)
We report here a convenient synthesis of optically pure α-aryl amino acids by enantioselective substitution of fluorobenzene tricarbonylchromium using the Schiff bases of L-alanine methyl ester with (1R,2R,5R)-2-hydroxy-3-pinanone in presence of LDA or deprotonated 2-(tert-butyl)-4-methyl-1,3-oxazolidin-5 one.
