1040749-30-1

Basic information

• Product Name: (S)-N-tert-butoxycarbonyl-3-fluoro-3-(4-methylphenyl)-2-oxindole
• Synonyms: (S)-N-tert-butoxycarbonyl-3-fluoro-3-(4-methylphenyl)-2-oxindole
• CAS NO: 1040749-30-1
• Molecular Weight: 341.382
• Mol File: 1040749-30-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: (S)-N-tert-butoxycarbonyl-3-fluoro-3-(4-methylphenyl)-2-oxindole(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-N-tert-butoxycarbonyl-3-fluoro-3-(4-methylphenyl)-2-oxindole(1040749-30-1)
• EPA Substance Registry System: (S)-N-tert-butoxycarbonyl-3-fluoro-3-(4-methylphenyl)-2-oxindole(1040749-30-1)

Safety Data

• Hazardous Substances Data: 1040749-30-1(Hazardous Substances Data)

Upstream product

• 1422007-75-7 C₂₀H₂₁NO₄ 
• 4294-57-9 para-methylphenylmagnesium bromide 
• 160858-75-3 1-tert-butoxycarbonylisatin 
• 1040749-57-2 1-(t-butoxycarbonyl)-2-oxo-3-(4-methylphenyl)-indolin-3-yl t-butyl carbonate 
• 862907-05-9 tert-butyl 3-(4-methylphenyl)-2-oxoindoline-1-carboxylate 

Relevant articles and documents

Expanding the Boxmi Ligand Family: Synthesis and Application of NON and NSN Ligands

Two synthetic strategies for a new family of neutral NON ligands featuring a bis(oxazolinylmethylidene)isobenzofuran framework (boxman) are reported. A Pd-mediated cyclization reaction forming the isobenzofuran core constitutes the key reaction in the eight-step synthetic route to the nonbackbone-methylated target compound H,Rboxman. In contrast, the introduction of two additional methyl groups provides stereochemical control during backbone construction and thereby access to the methylated derivative Me,Rboxman, which was synthesized in five steps and improved yields. In addition, the synthetic sequence was transferred to the thio analogue, providing access to the NSN ligand H,Rboxmene. Subsequent complexation experiments with iron and cobalt chloride precursors afforded the four-coordinated chlorido complexes Me,RboxmanMCl2 (R = Ph, iPr; M = Fe, Co) and established the boxman family as trans-chelating, bidentate bis(oxazoline) ligands. Application of the latter in the nickel(II)- and zinc(II)-catalyzed α-fluorination of β-ketoesters and oxindoles (up to 98percent yield and 94percent ee) demonstrated their suitability for enantioselective catalysis.

Comparative studies on the enantioselective fluorination of oxindoles with structurally modified N-fluorobenzenesulfonimides

Structurally modified N-fluorobenzenesulfonimides (NFSIs) have been used to study the enantioselective fluorination of oxindoles in the presence of a bis-cinchona alkaloid, (DHQD)2PHAL, as the catalyst. We observe that the NFSI analogues bearin

The synthesis of a new class of chiral pincer ligands and their applications in enantioselective catalytic fluorinations and the Nozaki-Hiyama-Kishi reaction

A new class of chiral tridentate N-donor pincer ligands, bis(oxazolinylmethylidene)isoindolines (boxmi), was synthesized in three steps starting from readily available phthalimides. Their reaction with ethyl (triphenylphosphoranylidene)acetate by means of