104182-98-1 Usage
Description
PHENYL-D5-ACETIC ACID, a deuterated compound, is a white solid with unique chemical properties. It is primarily utilized in the synthesis of deuterium-labeled pharmaceuticals, offering valuable insights into the behavior and metabolism of these compounds in biological systems.
Uses
Used in Pharmaceutical Synthesis:
PHENYL-D5-ACETIC ACID is used as a key intermediate in the synthesis of deuterium-labeled Diclofenac (D436450) and its metabolite 4'-Hydroxydiclofenac (H825225). These labeled compounds are essential for understanding the principal human metabolite of Diclofenac, which is crucial for drug development and optimization in the pharmaceutical industry.
Used in Research and Development:
In the field of research and development, PHENYL-D5-ACETIC ACID serves as a valuable tool for studying the effects of deuterium substitution on the pharmacokinetics, pharmacodynamics, and metabolic pathways of Diclofenac and its metabolites. This information can be vital for the development of more effective and safer drugs in the future.
Used in Drug Metabolism Studies:
PHENYL-D5-ACETIC ACID is used as a research compound to investigate the metabolic pathways of Diclofenac and its metabolites in the human body. This knowledge can help researchers understand how deuterium labeling affects the metabolism of drugs, potentially leading to improved drug design and personalized medicine approaches.
Used in Analytical Chemistry:
In analytical chemistry, PHENYL-D5-ACETIC ACID can be employed as a reference material or internal standard for the accurate quantification and identification of Diclofenac and its metabolites in various biological samples. This application is essential for ensuring the reliability and accuracy of analytical results in drug testing and quality control processes.
Check Digit Verification of cas no
The CAS Registry Mumber 104182-98-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,4,1,8 and 2 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 104182-98:
(8*1)+(7*0)+(6*4)+(5*1)+(4*8)+(3*2)+(2*9)+(1*8)=101
101 % 10 = 1
So 104182-98-1 is a valid CAS Registry Number.
104182-98-1Relevant articles and documents
Palladium-Catalyzed Distal C?H Selenylation of 2-Aryl Acetamides with Diselenides and Selenyl Chlorides
Gu, Linghui,He, Meicui,Ma, Wenbo,Tan, Yuqiang,Wang, Yang,Wang, Yuchi,Zhang, Chunran
supporting information, p. 5708 - 5715 (2020/12/01)
A convenient and effective method of palladium-catalyzed C?H selenylation of the 2-aryl acetamides assisted with removable 8-aminoquinoline with readily available diselenides and selenyl chlorides has been developed. This selenylation reaction is scalable and tolerates a wide range of functional groups, providing a straightforward way of the preparing unsymmetrical diaryl selenides and dibenzoselene-pinone. Preliminary mechanistic studies indicated that a single-electron transfer type mechanism and facile C?H metalation are operative. (Figure presented.).
Distal Weak Coordination of Acetamides in Ruthenium(II)-Catalyzed C?H Activation Processes
Bu, Qingqing,Rogge, Torben,Kotek, Vladislav,Ackermann, Lutz
supporting information, p. 765 - 768 (2018/01/17)
C?H activations with challenging arylacetamides were accomplished by versatile ruthenium(II) biscarboxylate catalysis. The distal C?H functionalization offers ample scope—including twofold oxidative C?H functionalizations and alkyne hydroarylations—throug
ETUDE STRUCTURALE DE DERIVES DU PHENYL-ETHANE
Lere-Porte, J. P.,Bonniol, A.,Petrissans, J.
, p. 77 - 88 (2007/10/02)
Analysis of the methylene bending modes of phenyl ethane derivatives is consistent with the existence of trans-gauche conformational equilibria in the dissolved state.The relative amounts of each conformer have been determined and agree well with previous