10420-70-9Relevant articles and documents
Iron- or Zinc-Mediated Synthetic Approach to Enantiopure Dihydroquinoxalinones
Li, Dazhi,Ollevier, Thierry
supporting information, p. 1273 - 1280 (2019/01/04)
A general and efficient synthesis of enantiopure dihydroquinoxalinones has been developed using naturally occurring amino acids as starting materials. The reductive cyclization of N-(o-nitroaryl)amino esters was performed by using iron and zinc metal under mild conditions in a water/ethyl acetate mixture. The corresponding dihydroquinoxalinones were obtained in moderate to high yields and high enantiomeric purity, among which 7 new compounds were unprecedented in the literature.