1042847-65-3

Basic information

• Product Name: C₁₆H₁₅F₂N₃O
• CAS NO: 1042847-65-3
• Molecular Weight: 303.311
• Mol File: 1042847-65-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₆H₁₅F₂N₃O(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₆H₁₅F₂N₃O(1042847-65-3)
• EPA Substance Registry System: C₁₆H₁₅F₂N₃O(1042847-65-3)

Safety Data

• Hazardous Substances Data: 1042847-65-3(Hazardous Substances Data)

Upstream product

• 26820-63-3 5-nitro-2-(pyrrolidin-1-yl)pyridine 
• 455-86-7 3,4-Difluorobenzoic acid 
• 92808-19-0 6-(pyrrolidin-1-yl)pyridin-3-amine 
• 76903-88-3 3,4-difluorobenzoyl chloride 

Relevant articles and documents

N -pyridyl and pyrimidine benzamides as KCNQ2/Q3 potassium channel openers for the treatment of epilepsy

A series of N-pyridyl benzamide KCNQ2/Q3 potassium channel openers were identified and found to be active in animal models of epilepsy and pain. The best compound 12 [ICA-027243, N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide] has an EC50 of 0.38 μM and is selective for KCNQ2/Q3 channels. This compound was active in several rodent models of epilepsy and pain but upon repeated dosing had a number of unacceptable toxicities that prevented further development. On the basis of the structure-activity relationships developed around 12, a second compound, 51, [N-(2-chloro-pyrimidin-5-yl)-3,4-difluoro- benzamide, ICA-069673], was prepared and advanced into a phase 1 clinical study. Herein, we describe the structure-activity relationships that led to the identification of compound 12 and to the corresponding pyrimidine 51.