1042987-87-0 Usage
Derivative of indazole
Indazole is a heterocyclic aromatic organic compound This compound is based on the indazole structure, which is a five-membered aromatic ring containing one nitrogen atom.
Structural features
Fluorine atom, methyl group, and phenyl ring The presence of these functional groups in the compound contributes to its versatility in synthesis and potential applications.
Versatile building block
Synthesis of various pharmaceutical and agrochemical compounds Due to its unique structure, this compound can be used as a starting material for creating a wide range of other compounds in the pharmaceutical and agrochemical industries.
Potential applications in medicinal chemistry
Pharmacophore, development of new drug candidates The compound's structure can be used as a pharmacophore, which is a part of a molecule responsible for the biological activity of a drug. This makes it a valuable component in the development of new drug candidates with improved therapeutic potential.
Enhanced biological activity
Improved therapeutic potential The presence of the fluorine atom and other structural features may contribute to increased biological activity, leading to more effective drugs.
Uses in agricultural purposes
Development of new chemical entities The compound may also be used in the creation of new chemical entities for agricultural purposes, such as pesticides or herbicides.
Check Digit Verification of cas no
The CAS Registry Mumber 1042987-87-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,4,2,9,8 and 7 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1042987-87:
(9*1)+(8*0)+(7*4)+(6*2)+(5*9)+(4*8)+(3*7)+(2*8)+(1*7)=170
170 % 10 = 0
So 1042987-87-0 is a valid CAS Registry Number.
1042987-87-0Relevant articles and documents
Rh(iii)-catalyzed, hydrazine-directed C-H functionalization with 1-alkynylcyclobutanols: A new strategy for 1: H -indazoles
Zhang, Lei,Chen, Junyu,Chen, Xiahe,Zheng, Xiangyun,Zhou, Jian,Zhong, Tianshuo,Chen, Zhiwei,Yang, Yun-Fang,Jiang, Xinpeng,She, Yuan-Bin,Yu, Chuanming
supporting information, p. 7415 - 7418 (2020/07/15)
Rh(iii)-catalyzed coupling of phenylhydrazines with 1-alkynylcyclobutanols was realized through a hydrazine-directed C-H functionalization pathway. This [4+1] annulation, based on the cleavage of a Csp-Csp triple bond in alkynylcyclobutanol, provides a new pathway to prepare diverse 1H-indazoles under mild reaction conditions. This journal is
Palladium-catalyzed direct C7-arylation of substituted indazoles
Naas, Mohammed,El Kazzouli, Sa?d,Essassi, El Mokhtar,Bousmina, Mosto,Guillaumet, Gérald
, p. 7286 - 7293 (2014/09/16)
A novel direct C7-arylation of indazoles with iodoaryls is described using Pd(OAc)2 as catalyst, 1,10-phenanthroline as ligand, and K 2CO3 as base in refluxing DMA. Direct C7-arylation of 3-substituted 1H-indazole containing an EWG on the arene ring gave the expected products in good isolated yields. In addition, a one-pot Suzuki-Miyaura/ arylation procedure leading to C3,C7-diarylated indazoles has been developed.
