1043534-06-0

Basic information

• Product Name: 2-(2-methoxy-5-phenyl-2,3-dihydrobenzo[1,4]dioxin-2-yl)-4,5-dihydro-1H-imidazole
• CAS NO: 1043534-06-0
• Molecular Weight: 310.353
• Mol File: 1043534-06-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(2-methoxy-5-phenyl-2,3-dihydrobenzo[1,4]dioxin-2-yl)-4,5-dihydro-1H-imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-methoxy-5-phenyl-2,3-dihydrobenzo[1,4]dioxin-2-yl)-4,5-dihydro-1H-imidazole(1043534-06-0)
• EPA Substance Registry System: 2-(2-methoxy-5-phenyl-2,3-dihydrobenzo[1,4]dioxin-2-yl)-4,5-dihydro-1H-imidazole(1043534-06-0)

Safety Data

• Hazardous Substances Data: 1043534-06-0(Hazardous Substances Data)

Upstream product

• 1133-63-7 3-phenylcatechol 
• 124-41-4 sodium methylate 
• 107-15-3 ethylenediamine 
• 920-37-6 2-Chloroacrylonitrile 

Relevant articles and documents

α2-adrenoreceptors profile modulation. 4. From antagonist to agonist behavior

The goal of the present study was to modulate the receptor interaction properties of known α2-adrenoreceptor (AR) antagonists to obtain novel α2-AR agonists with desirable subtype selectivity. Therefore, a phenyl group or one of its bioisosteres or aliphatic moieties with similar steric hindrance were introduced into the aromatic ring of the antagonist lead basic structure. The functional properties of the novel compounds allowed our previous observations to be confirmed. The high efficacy of 7, 12, and 13 as α2-AR agonists and the significant α2C-AR subtype selective activation displayed by 11 and 15 demonstrated that favorable interactions to induce α2-AR activation were formed between the pendant groups of the ligands and the aromatic cluster present in transmembrane domain 6 of the binding site cavity of the receptors.