104371-21-3

Basic information

• Product Name: R(+)-1-(PENTAFLUOROPHENYL)ETHANOL
• Synonyms: R(+)-1-(PENTAFLUOROPHENYL)ETHANOL;R(+)-ALPHA-METHYL-2,3,4,5,6-PENTAFLUOROBENZYL ALCOHOL;(R)-(+)-1-(PENTAFLUOROPHENYL)ETHANOL, FL UKABRAND CHIRASELECT REAGENT, 99+%;(r)-(+)-α-methyl-2,3,4,5,6-pentafluorobenzyl alcohol;(1R)-1-(Pentafluorophenyl)ethanol
• CAS NO: 104371-21-3
• Molecular Formula: C₈H₅F₅O
• Molecular Weight: 212.12
• Mol File: 104371-21-3.mol
• Article Data: 17

Chemical Properties

• Melting Point: 41-42 °C(lit.)
• Flash Point: 189 °F
• Appearance: /
• BRN: 5268492
• CAS DataBase Reference: R(+)-1-(PENTAFLUOROPHENYL)ETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: R(+)-1-(PENTAFLUOROPHENYL)ETHANOL(104371-21-3)
• EPA Substance Registry System: R(+)-1-(PENTAFLUOROPHENYL)ETHANOL(104371-21-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• F: 10
• Hazardous Substances Data: 104371-21-3(Hazardous Substances Data)

Upstream product

• 652-29-9 2',3',4',5',6'-pentafluoroacetophenone 
• 653-37-2 perfluorobenzaldehyde 
• 544-97-8 dimethyl zinc(II) 
• 108-05-4 vinyl acetate 
• 830-50-2 1-(pentafluorophenyl)ethanol 
• 108-22-5 Isopropenyl acetate 
• 344-04-7 bromopentafluorobenzene 

Relevant articles and documents

Enantioselectivity in the Noyori?Ikariya asymmetric transfer hydrogenation of ketones

Asymmetric transfer hydrogenation (ATH) is an important catalytic process in the fragrance and pharmaceutical industries. The Noyori?Ikariya chiral molecular ruthenium complex has been the catalyst of choice for this reaction for over 25 years. The mechan

Asymmetric Catalytic Meerwein-Ponndorf-Verley Reduction of Ketones with Aluminum(III)-VANOL Catalysts

We report herein an efficient aluminum-catalyzed asymmetric MPV reduction of ketones with broad substrate scope and excellent yields and enantiomeric inductions. A variety of aromatic (both electron-poor and electron-rich) and aliphatic ketones were converted to chiral alcohols in good yields with high enantioselectivities (26 examples, 70-98percent yield and 82-99percent ee). This method operates under mild conditions (-10 °C) and low catalyst loading (1-5 mol percent). Furthermore, this process is catalyzed by the earth-abundant main-group element aluminum and employs 2-propanol as the hydride source.

Asymmetric Hydrogenation of Aryl Perfluoroalkyl Ketones Catalyzed by Rhodium(III) Monohydride Complexes Bearing Josiphos Ligands

The asymmetric hydrogenation of 2,2,2-trifluoroacetophenones and aryl perfluoroalkyl ketones was developed using a unique, well-defined chloride-bridged dinuclear rhodium(III) complex bearing Josiphos-type diphosphine ligands. These complexes were prepared from [RhCl(cod)]2, Josiphos ligands, and hydrochloric acid. As catalyst precursors, they allow for the efficient and enantioselective synthesis (up to 99 % ee) of chiral secondary alcohols with perfluoroalkyl groups. This system does not require an activating base for the hydrogenation of 2,2,2-trifluoroacetophenones. Additionally, the enantioselective C=O hydrogenations of 2-phenyl-3-(haloacetyl)-indoles, a class of privileged structures in medicinal chemistry, is reported for the first time.