104384-66-9Relevant articles and documents
Multicomponent synthesis, in?vitro cytotoxic evaluation and molecular modelling studies of polyfunctionalized pyrazolo[3,4-b]pyridine derivatives against three human cancer cell lines
Aggarwal, Ranjana,Kumar, Suresh,Sadana, Rachna,Guzman, Andrea,Kumar, Virender
supporting information, p. 3308 - 3324 (2021/09/16)
A series of diversely polyfunctionalized pyrazolo[3,4-b]pyridines were synthesized by the multicomponent reaction of phenyl/benzothiazolylhydrazine and 3-oxo-3-arylpropanenitrile with 1,3-diketones under solvent-free and solvent-mediated conditions. Nineteen pyrazolo[3,4-b]pyridine derivatives were screened for their anti-cancer activity against three human cancer cell lines namely NALM-6, SB-ALL and MCF-7. Non-fluorinated 1-(benzothiazolyl)pyrazolo[3,4-b]pyridines (6a–d) displayed better cytotoxicity results as compared to other tested derivatives. The compound 1-(benzothiazolyl)-4,6-dimethyl-3-(4-chlorophenyl)pyrazolo[3,4-b]pyridine, 6b, was identified as the most active derivative with 53% cell growth inhibition nearly equal to the standard drug doxorubicin (58%), in close agreement to drug-likeness and drug score predictions. Among the fluorinated derivatives, compound 2-(3-(4-chlorophenyl)-4-methyl-6-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)benzo[d]thiazole, 12c, was identified as hit compound with 46-39% cell growth inhibition against all the tested cell lines. Compound 6b was found to display suitable binding when docked inside the active site of Aurora-A kinase enzyme.
NEW PYRAZOLOPYRIDINE AND PYRAZOLOPYRIMIDINE DERIVATIVES FROM 4-ACETYL-5-AMINO-1,3-DIPHENYLPYRAZOLE
Piaz, Vittorio Dal,Ciciani, Giovanna,Chimichi, Stefano
, p. 2639 - 2644 (2007/10/02)
4-Acetyl-5-amino-1,3-diphenylpyrazole (1) undergoes cyclization with compounds of type R-CH2X (X=COCH3 and/or COPh, R=H and CH3CO; X=R=CN) and with formamide to give new pyrazolopyridine and pyrazolopyrimidine derivatives, respectively.
