1044518-75-3 Usage
Description
(4R-cis)-6-formyl-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester is a complex organic compound with a unique molecular structure. It is characterized by its 1,3-dioxane ring, a formyl group at the 6-position, and a tert-butyl ester group at the 4-position. (4R-cis)-6-formyl-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester is a chiral molecule with the R-configuration at the 4-position and a cis-configuration at the 6-position. Its molecular formula is C13H22O5, and it has a molecular weight of 258.31 g/mol.
Uses
Used in Pharmaceutical Industry:
(4R-cis)-6-formyl-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester is used as an intermediate in the synthesis of various pharmaceutical compounds. Its unique structure and functional groups make it a valuable building block for the development of new drugs with potential therapeutic applications.
Used in Organic Synthesis:
(4R-cis)-6-formyl-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester is used as a versatile reagent in organic synthesis. Its formyl and ester groups can be utilized in various chemical reactions, such as reduction, oxidation, and esterification, to produce a wide range of organic compounds with diverse applications.
Used in the Synthesis of Amphotericin B:
(4R-cis)-6-formyl-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester is used as a key intermediate in the synthesis of Amphotericin B, a potent antifungal drug. Its unique structure and functional groups play a crucial role in the formation of the final product, contributing to the drug's efficacy against various fungal infections.
Check Digit Verification of cas no
The CAS Registry Mumber 1044518-75-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,4,4,5,1 and 8 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1044518-75:
(9*1)+(8*0)+(7*4)+(6*4)+(5*5)+(4*1)+(3*8)+(2*7)+(1*5)=133
133 % 10 = 3
So 1044518-75-3 is a valid CAS Registry Number.
1044518-75-3Relevant articles and documents
A statin intermediate and its derivatives
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Paragraph 0039; 0040, (2017/08/25)
The invention discloses a preparation method of a statin intermediate and derivatives thereof. The preparation method comprises the steps of: preparing to obtain a compound in a formula (II) through oxidation reaction among a compound in a formula IV, DMSO (dimethylsulphoxide) and alkali in the existence of an alkali metal salt catalyst, and obtaining a compound in a formula (I) by base catalysis through condensation of the compound in the formula (II) and a compound in a formula (III), wherein in the formulas, X is halogens, R is substituted or non-substituted alkyl groups of C1-C6 and alkane cyclic groups or aryl groups of C3-C5, substituent groups of R are the aryl groups, and R1 is selected from one or several of the alkyl groups of C1-C6 and the halogens. Compared with the prior art, the preparation method has the advantages that the compound in the formula IV is not esterified and hydrolyzed for preparing alcohol, then aldehyde (compound in the formula II) is prepared through oxidation, and the compound in the formula II is directly prepared from the compound in the formula IV in one step. The preparation method has the advantages of short steps, simple operation and suitability for industrial production.
Synthesis of 35-deoxy amphotericin B methyl ester: A strategy for molecular editing
Szpilman, Alex M.,Cereghetti, Damiano M.,Wurtz, Nicholas R.,Manthorpe, Jeffrey M.,Carreira, Erick M.
supporting information; experimental part, p. 4335 - 4338 (2009/02/08)
(Chemical Presented) A modular strategy for the assembly of amphotericin B analogues with modifications in the macrolactone ring relies on the efficient gram-scale synthesis of all major and minor motifs of amphotericin B. Proof of concept has been achieved by the preparation of the 35-deoxy aglycone en route to the long-sought-after 35-deoxy analogue of amphotericin B.
