1044598-91-5

Basic information

• Product Name: 4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]benzoic Acid
• Synonyms: 4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]benzoic Acid;4-[4-[[2-(4-Chlorophenyl)-5,5-diMethyl-1-cyclohexenyl]Methyl]-1-;4-(4-{[2-(4-chlorophenyl)-5,5-diMethylcyclohex-1-en-1-yl]Methyl}piperazin-1-yl)benzoic acid;4-(4-((4'-Chloro-4,4-diMethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)Methyl)piperazin-1-yl)benzoic acid;Benzoic acid, 4-[4-[[2-(4-chlorophenyl)-5,5-diMethyl-1-cyclohexen-1-yl]Methyl]-1-piperazinyl]-;4-(4-((2-(4-Chlorophenyl)-5,5-diMethylcyclohex-1-enyl)Methyl)piperazin-1-yl)benzoic acid;4-(4-((4'-Chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)benzo;4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexenyl]methyl]-1-piperazinyl]benzoic acid
• CAS NO: 1044598-91-5
• Molecular Formula: C₂₆H₃₁ClN₂O₂
• Molecular Weight: 438.98954
• Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 1044598-91-5.mol
• Article Data: 6

Chemical Properties

• Melting Point: 191-193°C
• Appearance: /
• Storage Temp.: Refrigerator
• Solubility: DMSO, Methanol
• CAS DataBase Reference: 4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]benzoic Acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]benzoic Acid(1044598-91-5)
• EPA Substance Registry System: 4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]benzoic Acid(1044598-91-5)

Safety Data

• Hazardous Substances Data: 1044598-91-5(Hazardous Substances Data)

Usage

Description

4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]benzoic Acid is a complex organic compound characterized by its pale pink solid appearance. It features a unique molecular structure that includes a cyclohexenyl ring, a chlorophenyl group, and a piperazinyl moiety attached to a benzoic acid backbone. 4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]benzoic Acid serves as an intermediate in the synthesis of biologically active molecules, specifically those involved in regulating cell death and promoting apoptosis.

Uses

Used in Pharmaceutical Industry:
4-[4-[[2-(4-Chlorophenyl)-5,5-dimethyl-1-cyclohexen-1-yl]methyl]-1-piperazinyl]benzoic Acid is used as an intermediate in the production of cell death regulators and apoptosis promoters. Its role in the synthesis of these biologically active molecules is crucial for developing new therapeutic agents that can modulate cellular processes and combat diseases associated with uncontrolled cell growth or resistance to apoptosis.
As an intermediate, this compound contributes to the development of pharmaceuticals targeting various diseases, including cancer, where the regulation of cell death is a critical aspect of treatment. By promoting apoptosis, these regulators can help eliminate cancerous cells and potentially reduce the severity or progression of the disease.

Upstream product

• 80518-57-6 ethyl 4-(piperazin-1-yl)benzoate 
• 1065604-58-1 ethyl 4-(4-((2-bromo-5,5-dimethylcyclohex-1-enyl)methyl)piperazin-1-yl)benzoate 
• 451-46-7 4-fluorobenzoic acid ethyl ester 
• 1027345-22-7 6-(bromomethyl)-4'-chloro-4,4-dimethyl-2,3,4,5-tetrahydro-1,1'-biphenyl 
• 1027345-21-6 (4'-chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methanol 
• 1202186-71-7 4-chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1-biphenyl]-2-carbaldehyde 
• 1065604-70-7 ethyl 4-(4-((4'-chloro-4,4-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl) benzoate 
• 1044598-93-7 tert-butyl 4-(4-{[2-(4-chlorophenyl)-2-hydroxy-5,5-dimethylcyclohexyl]methyl}piperazin-1-yl)benzoate 

Downstream Products

• 923564-51-6 navitoclax 
• 852811-25-7 (R)-4-(4-((2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-enyl)methyl)piperazin-1-yl)-N-(4-(4-(dimethylamino)-1-(phenylthio)butan-2-ylamino)-3-nitrophenylsulfonyl)benzamide 

Relevant articles and documents

INHIBITING B-CELL LYMPHOMA 2 (BCL-2) AND RELATED PROTEINS

Novel compounds inhibiting anti-apoptosis proteins B-cell lymphoma 2 (Bcl-2) and Bcl-XL include compounds of formula (I) and formula (II) disclosed herein, as well as liposome compositions comprising Bcl-2 inhibitor compounds. These compositions are usefu

Profiling small molecule inhibitors against helix-receptor interactions: The Bcl-2 family inhibitor BH3I-1 potently inhibits p53/hDM2

We validate a practical methodology for the rapid profiling of small molecule inhibitors of protein-protein interactions. We find that a well known BH3 family inhibitor can potently inhibit the p53/hDM2 interaction.

An efficient synthesis of ABT-263, a novel inhibitor of antiapoptotic Bcl-2 proteins

ABT-263, a newly developed Bcl-2 inhibitor, was efficiently synthesized. The key intermediates 4-(4-{[2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-enyl] methyl}piperazin-1-yl)benzoic acid and 4-fluoro-3-[(trifluoromethyl)sulfonyl] benzenesulfonamide were eff