1044813-00-4Relevant articles and documents
Stereoselective synthesis of 4′-selenonucleosides using the Pummerer glycosylation reaction
Jayakanthan, Kumarasamy,Johnston, Blair D.,Pinto, B. Mario
, p. 1790 - 1800 (2008)
The syntheses of four selenonucleosides, namely 4′-β-selenoadenosine, -cytidine, -thymidine, and -uridine are described. Commercially available d-ribonolactone was converted to the key intermediate 1,4-anhydro-4-seleno-d-ribitol in seven steps in overall excellent yield. Oxidation of the seleno-d-ribitol with MCPBA gave a single diastereomeric selenoxide in excellent yield, which upon Pummerer reaction in the presence of silylated purine or pyrimidine bases gave stereoselectively the corresponding 4′-β-selenonucleosides. The stereochemistry at the anomeric center was determined by means of 1D-NOE experiments.
ANTIVIRAL AZASUGAR-CONTAINING NUCLEOSIDES
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Page/Page column 95, (2014/06/11)
Disclosed are compounds comprising an azasugar attached to a heterocyclic base, including pharmaceutically acceptable salts thereof, suitable for use in inhibiting viral RNA polymerase activity or viral replication, and treating viral infections. The compounds are characterized, in part, by favorable pharmacokinetics for the active pharmaceutical ingredient, particularly in conjunction with enteral administration, including, in particular, oral administration. Also disclosed are pharmaceutical compositions comprising one or more compounds mentioned above, or pharmaceutically acceptable salts thereof, as well as methods for preparing same. Also provided are methods for inhibiting viral RNA polymerase activity, viral replication, and treating viral infections.
COMPOSITIONS AND METHODS FOR INHIBITING VIRAL POLYMERASE
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Page/Page column 76, (2013/11/05)
Provided are compounds of Formula (I) as described herein. Compounds of Formula (I) are useful in methods of inhibiting viral RNA polymerase activity and viral replication. Also provided are pharmaceutical compositions comprising compounds of Formula (I), as well as methods of treating viral infections using compounds of Formula (I).