1044813-69-5Relevant articles and documents
Divergent synthesis of a pochonin library targeting HSP90 and in vivo efficacy of an identified inhibitor
Barluenga, Sofia,Wang, Cuihua,Fontaine, Jean-Gonzague,Aouadi, Kaiss,Beebe, Kristin,Tsutsumi, Shinji,Neckers, Len,Winssinger, Nicolas
scheme or table, p. 4432 - 4435 (2009/02/08)
(Chemical Equation Presented) Make a clean breast of it: The generation of a library of pochonin Dderivatives by a solid-phase approach has led to the discovery of pochoxime (see scheme), a potent inhibitor of the heat-shock protein 90, with over 100-fold improved incellular activity. Pochoxime was found to be effective in breast tumor xenografts, leading to a reduction in the tumor size.
