1044872-40-3

Basic information

• Product Name: 2-Amino-4,6-dichloro-nicotinicacidmethylester
• Synonyms: 2-Amino-4,6-dichloro-nicotinicacidmethylester;2-Amino-4,6-dichloropyridine-3-carboxylic acid methyl ester;Methyl 2-amino-4,6-dichloropyridine-3-carboxylate;Methyl 2-aMino-4,6-dichloronicotinate;3-Pyridinecarboxylicacid, 2-amino-4,6-dichloro-, methyl ester;2-amino-4,6-dichloro-, methyl ester
• CAS NO: 1044872-40-3
• Molecular Formula: C₇H₆Cl₂N₂O₂
• Molecular Weight: 221.04074
• EINECS: 1533716-785-6
• Mol File: 1044872-40-3.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 319.135 °C at 760 mmHg
• Flash Point: 146.808 °C
• Appearance: /
• Density: 1.506
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 2-Amino-4,6-dichloro-nicotinicacidmethylester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-4,6-dichloro-nicotinicacidmethylester(1044872-40-3)
• EPA Substance Registry System: 2-Amino-4,6-dichloro-nicotinicacidmethylester(1044872-40-3)

Safety Data

• Hazardous Substances Data: 1044872-40-3(Hazardous Substances Data)

Usage

Description

2-Amino-4,6-dichloro-nicotinicacidmethylester, also known as Methyl 2-Amino-4,6-dichloropyridine-3-carboxylate, is an organic compound with the chemical formula C7H6Cl2N2O2. It is a derivative of nicotinic acid, featuring a methyl ester group, two chlorine atoms at the 4 and 6 positions, and an amino group at the 2 position. 2-Amino-4,6-dichloro-nicotinicacidmethylester is known for its potential applications in the synthesis of various pharmaceuticals and agrochemicals.

Uses

Used in Pharmaceutical Industry:
2-Amino-4,6-dichloro-nicotinicacidmethylester is used as an intermediate in the synthesis of macrocyclic broad-spectrum antibiotics. These antibiotics are designed to target a wide range of bacterial infections, making them valuable in treating various diseases caused by different types of bacteria.
Used in Agrochemical Industry:
Although not explicitly mentioned in the provided materials, 2-Amino-4,6-dichloro-nicotinicacidmethylester may also have potential applications in the agrochemical industry. Given its structural features, it could be used as a precursor in the development of new pesticides or herbicides, contributing to more effective and targeted crop protection strategies.

Upstream product

• 1830-54-2 3-oxopentanedioic acid dimethyl ester 
• 420-04-2 CYANAMID 
• 523992-26-9 methyl 2-amino-4,6-dihydroxypyridine-3-carboxylate 

Downstream Products

• 1262132-81-9 2-({[7-hydroxy-5-(2-phenylethyl)-[1,2,4]triazolo[1,5-a]pyridin-8-yl]carbonyl}amino)acetic acid 
• 1262133-52-7 C₁₆H₁₄ClN₃O₂ 
• 1262133-53-8 7-chloro-5-(2-phenylethyl)-[1,2,4]triazolo[1,5-a]pyridine-8-carboxylic acid 
• 1262133-54-9 methyl 2-({[7-chloro-5-(2-phenylethyl)-[1,2,4]triazolo[1,5-a]pyridin-8-yl]carbonyl}amino)acetate 
• 1253732-89-6 2-[4-(2-aminoethoxy)-3,5-dimethylphenyl]-5,7-dimethoxy-3H-pyrido[2,3-d]pyrimidin-4-one 
• 1253732-84-1 N-{2-[4-(5,7-dimethoxy-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl)-2,6-dimethylphenoxy]ethyl}acetamide 
• 1253733-03-7 N-[4-(5,7-dimethoxy-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl)-2,6-dimethylbenzyl]acetamide 
• 1044871-12-6 2-(4-(bis(2-hydroxyethyl)amino)phenyl)-5,7-dimethoxypyrido[2,3-d]pyrimidin-4(3H)-one 
• 1044871-00-2 2-[4-(2-hydroxy-ethoxy)-3,5-dimethyl-phenyl]-5,7-dimethoxy-3H-pyrido[2,3-d]pyrimidin-4-one 
• 1044870-97-4 2-(4-hydroxy-3,5-dimethylphenyl)-5,7-dimethoxypyrido[2,3-d]pyrimidin-4(3H)-one 

Relevant articles and documents

METHOD FOR PRODUCING TRIAZOLOPYRIDINE COMPOUND

The present invention relates to a novel method for producing a triazolopyridine compound or a salt thereof having a PHD inhibitory action and useful for treating or preventing diseases caused by decreased production of EPO, or the like. The present invention provides a method for producing 2-({[7-hydroxy-5-(2-phenylethyl)-[1,2,4]triazolo[1,5-a]pyridin-8-yl]carbonyl}amino)acetic acid comprising a step of reacting Compound [VI]: wherein R61, R62 and R111 are as defined in the specification, or a salt thereof.

COMPOUNDS AND METHODS OF USE

This disclosure provides compounds and compositions and methods of using those compounds and compositions to treat diseases and disorders associated with excessive transforming growth factor-beta (TGFβ) activity. This disclosure also provides methods of using the compounds in combination with one or more cancer immunotherapies.

TREATMENT OF DISEASES BY EPIGENETIC REGULATION

The present disclosure provides non-naturally occurring polyphenol compounds that inhibit the bromodomain and extra terminal domain (BET) proteins. The disclosed compositions and methods can be used for treatment and prevention of diseases or disorders that are susceptible to administration of a BET inhibitor.