104504-02-1

Basic information

• Product Name: 4-methyl-N-(tosyloxy)benzenesulfonamide
• Synonyms: 4-methyl-N-(tosyloxy)benzenesulfonamide
• CAS NO: 104504-02-1
• Molecular Weight: 341.409
• Mol File: 104504-02-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4-methyl-N-(tosyloxy)benzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methyl-N-(tosyloxy)benzenesulfonamide(104504-02-1)
• EPA Substance Registry System: 4-methyl-N-(tosyloxy)benzenesulfonamide(104504-02-1)

Safety Data

• Hazardous Substances Data: 104504-02-1(Hazardous Substances Data)

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 183253-89-6 (2S,3S)-2-formyl-3-methyl-1-(toluene-4-sulfonyl)-aziridine 
• 1266373-47-0 (2S,3R)-2-ethyl-3-propyl-1-tosylaziridine-2-carbaldehyde 
• 1266373-48-1 (S)-2-pentyl-1-tosylaziridine-2-carbaldehyde 
• 41253-06-9 N,N'-bis(4-methylphenyl)sulfamide 

Relevant articles and documents

Enantioselective Preparation, Conformational Analysis and Absolute Configuration of Highly Substituted Aziridines

The first example of organocatalytic aziridination reaction of α-substituted-α,β-unsaturated ketones is presented. The reaction was found to be highly enantio- and diastereoselective, yielding N-tosylated aziridines. Low-temperature nuclear magnetic reson

Efficient Synthesis of Unsymmetrical Sulfamides via a Lossen-Like Rearrangement

A convenient one-pot synthesis of unsymmetrical sulfamides via a Lossen-like rearrangement is reported. The protocol operates under simple conditions at room temperature and does not require an inert atmosphere and a dry solvent. The ability of N-hydroxy arenesulfonamide O-derivatives to generate under mild conditions N-sulfonylimine intermediates was a trigger point for developing a general synthetic strategy towards unsymmetrical sulfamides. The synthetic potential of the methodology has been investigated by preparing cyclic sulfamides and new potential chiral organocatalysts. (Figure presented.) .