1045712-54-6

Basic information

• Product Name: C₃₆H₄₉N₅O₇
• CAS NO: 1045712-54-6
• Molecular Weight: 663.814
• Mol File: 1045712-54-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₃₆H₄₉N₅O₇(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₆H₄₉N₅O₇(1045712-54-6)
• EPA Substance Registry System: C₃₆H₄₉N₅O₇(1045712-54-6)

Safety Data

• Hazardous Substances Data: 1045712-54-6(Hazardous Substances Data)

Upstream product

• 35661-39-3 N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine 
• 163619-04-3 1-tert-butoxycarbonyl-N-[(9-fluorenyl)methoxycarbonyl]-D-tryptophan 
• 220498-02-2 (R)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-phenylpropanoic acid 
• 126631-93-4 8-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)octanoic acid 

Relevant articles and documents

Synthetic and pharmacological studies on new simplified analogues of the potent actin-targeting Jaspamide

In the recent years, we focused our attention on the cyclodepsipeptide Jaspamide 1, an interesting marine metabolite, possessing a potent inhibitory activity against breast and prostate cancer, as a consequence of its ability to disrupt actin cytoskeleton dynamics. Although its biological profile has been well determined, many mechanistic details are still missing in terms of molecular target identification. For this reason, we decided to synthetically modify the natural metabolite, obtaining small arrays of unnatural variants useful to illuminate the structural requirements essential for the activity. Here, we report the synthesis of seven new Jaspamide analogues 2-8, containing, as the parent compound, a β-amino acid in the cyclopeptide backbone. Their biological profile is also described.