1046154-80-6

Basic information

• Product Name: C₁₇H₁₂ClFN₂O₂
• CAS NO: 1046154-80-6
• Molecular Weight: 330.746
• Mol File: 1046154-80-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₇H₁₂ClFN₂O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₇H₁₂ClFN₂O₂(1046154-80-6)
• EPA Substance Registry System: C₁₇H₁₂ClFN₂O₂(1046154-80-6)

Safety Data

• Hazardous Substances Data: 1046154-80-6(Hazardous Substances Data)

Upstream product

• 108-24-7 acetic anhydride 
• 5219-86-3 3-Amino-6-chloro-4-(2-fluoro-phenyl)-1H-quinolin-2-one 

Relevant articles and documents

Synthesis and in vitro anti-hepatitis B virus activities of 4-aryl-6-chloro-quinolin-2-one and 5-aryl-7-chloro-1,4-benzodiazepine derivatives

A series of 4-aryl-6-chloro-quinolin-2-ones and 5-aryl-7-chloro-1,4-benzodiazepine were synthesized and assayed for their in vitro anti-hepatitis B virus activities and cytotoxicities for the first time. Some of the tested compounds were active against HBsAg and HBeAg secretion in Hep G2.2.15 cells. Compound 5c showed IC50 of 0.074 and 0.449 mM on HBsAg and HBeAg secretions, respectively, which were 10 times higher than that of its analog 4c and led to better selective index (SI) values (SI = 23.2 and 3.4, respectively).