1046357-40-7

Basic information

• Product Name: (2S)-4-nitrooxy-butyl 2-(tert-butoxycarbonylamino)-3-(4-((2-((9R,10S,11S,13S,16R,17S)-9-fluoro-11-hydroxy-16,17-((1-methylethylidene)bis(oxy))-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxo-ethoxy)carbonyloxy)phenyl)propanoate
• Synonyms: (2S)-4-nitrooxy-butyl 2-(tert-butoxycarbonylamino)-3-(4-((2-((9R,10S,11S,13S,16R,17S)-9-fluoro-11-hydroxy-16,17-((1-methylethylidene)bis(oxy))-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxo-ethoxy)carbonyloxy)phenyl)propanoate
• CAS NO: 1046357-40-7
• Molecular Weight: 858.913
• Mol File: 1046357-40-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S)-4-nitrooxy-butyl 2-(tert-butoxycarbonylamino)-3-(4-((2-((9R,10S,11S,13S,16R,17S)-9-fluoro-11-hydroxy-16,17-((1-methylethylidene)bis(oxy))-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxo-ethoxy)carbonyloxy)phenyl)propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-4-nitrooxy-butyl 2-(tert-butoxycarbonylamino)-3-(4-((2-((9R,10S,11S,13S,16R,17S)-9-fluoro-11-hydroxy-16,17-((1-methylethylidene)bis(oxy))-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxo-ethoxy)carbonyloxy)phenyl)propanoate(1046357-40-7)
• EPA Substance Registry System: (2S)-4-nitrooxy-butyl 2-(tert-butoxycarbonylamino)-3-(4-((2-((9R,10S,11S,13S,16R,17S)-9-fluoro-11-hydroxy-16,17-((1-methylethylidene)bis(oxy))-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxo-ethoxy)carbonyloxy)phenyl)propanoate(1046357-40-7)

Safety Data

• Hazardous Substances Data: 1046357-40-7(Hazardous Substances Data)

Upstream product

• 1046357-36-1 4-nitrooxy-butyl (S)-2-(tert-butoxycarbonylamino)-3-(4-((4-nitrophenoxy)carbonyloxy)phenyl)propanoate 
• 76-25-5 triamcinolone acetonide 

Downstream Products

• 1046357-44-1 4-nitrooxy-butyl (S)-2-amino-3-(4-((2-((9R,10S,11S,13S,16R,17S)-9-fluoro-11-hydroxy-16,17-((1-methylethylidene)bis(oxy))-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethoxy)carbonyloxy)phenyl)propanoate 

Relevant articles and documents

NITRIC OXIDE RELEASING STEROIDS

The invention relates to nitrooxyderivative of corticosteroids of generalformula (I) and pharmaceutically acceptable salts or stereoisomers thereof wherein R is the corticosteroid residue of formula (II): wherein: R1 is OH, R2-CH3, or R1 and R2 are taken together to form a group of formula (III) R3 is C1 or F; R4 is H or F; wherein R1, R2, R3 and R4 can be linked to the correspondent carbon atoms of the steroidal structure in position β or β; with the proviso that: when R1 and R2 are the group of formula (III) then R3 is F and R4 is H or F; The compounds are useful in the treatment of respiratory diseases, inflammatory diseases, dermatological diseases and oculardiseases.