10468-90-3 Usage
Description
3-IODO-L-THYRONINE, also known as 3-iodothyronine, is a metabolite of thyroid hormone that plays a crucial role in the regulation of various physiological processes in the human body. It is characterized by its tan-to-light brown solid appearance and is of significant interest in the medical field due to its potential applications in the early detection and treatment of hypothyroidism.
Uses
Used in Medical Applications:
3-IODO-L-THYRONINE is used as a diagnostic marker for the early detection of congenital or drug-induced hypothyroidism in the developing human fetus. This application is particularly important as timely identification and treatment of hypothyroidism can prevent severe developmental issues and intellectual disabilities in newborns.
Used in Pharmaceutical Industry:
3-IODO-L-THYRONINE is used as an active pharmaceutical ingredient for the treatment of congenital or drug-induced hypothyroidism. Its role in regulating the body's metabolic processes makes it a valuable compound in the development of medications aimed at managing thyroid hormone levels and addressing related health concerns.
Check Digit Verification of cas no
The CAS Registry Mumber 10468-90-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,4,6 and 8 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 10468-90:
(7*1)+(6*0)+(5*4)+(4*6)+(3*8)+(2*9)+(1*0)=93
93 % 10 = 3
So 10468-90-3 is a valid CAS Registry Number.
InChI:InChI=1/C15H14INO4/c16-12-7-9(8-13(17)15(19)20)1-6-14(12)21-11-4-2-10(18)3-5-11/h1-7,13,18H,8,17H2,(H,19,20)/t13-/m0/s1
10468-90-3Relevant articles and documents
Varcoe,Warburton
, p. 2711,2714 (1960)
Biomimetic deiodination of thyroid hormones and iodothyronamines-a structure-activity relationship study
Mondal, Santanu,Mugesh, Govindasamy
supporting information, p. 9490 - 9500 (2016/10/22)
Mammalian selenoenzymes, iodothyronine deiodinases (DIOs), catalyze the tyrosyl and phenolic ring deiodination of thyroid hormones (THs) and play an important role in maintaining the TH concentration throughout the body. These enzymes also accept the decarboxylated thyroid hormone metabolites, iodothyronamines (TAMs), as substrates for deiodination. Naphthalene-based selenium and/or sulphur-containing small molecules have been shown to mediate the regioselective tyrosyl ring deiodination of thyroid hormones and their metabolites. Herein, we report on the structure-activity relationship studies of a series of peri-substituted selenium-containing naphthalene derivatives for the deiodination of thyroid hormones and iodothyronamines. Single crystal X-ray crystallographic and 77Se NMR spectroscopic studies indicated that the intramolecular Se?X (X = N, O and S) interactions play an important role in the deiodinase activity of the synthetic mimics. Furthermore, the decarboxylated metabolites, TAMs, have been observed to undergo slower tyrosyl ring deiodination than THs by naphthyl-based selenium and/or sulphur-containing synthetic deiodinase mimics and this has been explained on the basis of the strength of Se?I halogen bonding formed by THs and TAMs.
Catalytic tritiation of iodized phenols. Preparation of tritiated estradiol, tyrosine and thyronine.
JACQUEMIN,MICHEL,NUNEZ,ROCHE
, p. 1904 - 1906 (2007/11/09)
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