104700-36-9

Basic information

• Product Name: 2-Butenoic acid, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-, ethyl ester, (2E)-
• CAS NO: 104700-36-9
• Molecular Formula: C11H19NO4
• Molecular Weight: 229.276
• Mol File: 104700-36-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Butenoic acid, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-, ethyl ester, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Butenoic acid, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-, ethyl ester, (2E)-(104700-36-9)
• EPA Substance Registry System: 2-Butenoic acid, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-, ethyl ester, (2E)-(104700-36-9)

Safety Data

• Hazardous Substances Data: 104700-36-9(Hazardous Substances Data)

Upstream product

• 137618-48-5 tert-butyl N-(2,3-dihydroxypropyl)carbamate 

Downstream Products

• 625457-56-9 (R)-ethyl 4-[(tert-butoxycarbonyl)amino]-3-(4-chlorophenyl)butanoate 
• 75178-87-9 (4-hydroxybutyl)carbamic acid tert-butyl ester 
• 128490-08-4 (E)-tert-butyl (4-hydroxybut-2-en-1-yl)carbamate 

Relevant articles and documents

Tumor-Cell-Specific Targeting of Ibrutinib: Introducing Electrostatic Antibody-Inhibitor Conjugates (AiCs)

Ibrutinib is an inhibitor of Bruton's tyrosine kinase that has been approved for the treatment of patients with chronic lymphocytic leukemia, mantle cell lymphoma and Waldenstrom's macroglobulinemia and is connected with toxicities. To minimize its toxicities, we linked ibrutinib to a cell-targeted, internalizing antibody. To this end, we synthesized a poly-anionic derivate, ibrutinib-Cy3.5, that retains full functionality. This anionic inhibitor is complexed by our anti-CD20-protamine targeting conjugate and free protamine, and thereby spontaneously assembles into an electrostatically stabilized vesicular nanocarrier. The complexation led to an accumulation of the drug driven by the CD20 antigen internalization to the intended cells and an amplification of its pharmacological effectivity. In vivo, we observed a significant enrichment of the drug in xenograft lymphoma tumors in immune-compromised mice and a significantly better response to lower doses compared to the original drug.