1047645-82-8 Usage
Description
GSK2110183B, also known as Afuresertib, is a selective, orally bioavailable inhibitor of Akt1, 2, and 3 with Ki values of 0.08, 2, and 2.6 nM, respectively. It is a pharmaceutical compound that preferentially inhibits the proliferation of human cancer cell lines with Akt pathway activation and various cell lines derived from hematologic malignancies with minimal effect on glucose homeostasis. Afuresertib demonstrates activity against multiple myeloma in both preclinical and clinical models.
Uses
Used in Oncology:
GSK2110183B is used as an inhibitor for the treatment of cancer, particularly for human cancer cell lines with Akt pathway activation and various cell lines derived from hematologic malignancies. It targets and inhibits the Akt1, 2, and 3 proteins, which play a crucial role in cell survival, growth, and proliferation, thereby disrupting the cancer cell's ability to grow and divide.
Used in Multiple Myeloma Treatment:
GSK2110183B is used as a therapeutic agent for the treatment of multiple myeloma, a type of blood cancer. It has demonstrated activity against multiple myeloma in both preclinical and clinical models, making it a promising candidate for further research and development in this area.
Used in Drug Development:
GSK2110183B is used as a research tool for the development of new drugs targeting the Akt pathway. Its selective inhibition of Akt1, 2, and 3 makes it a valuable compound for studying the role of these proteins in various diseases, including cancer, and for identifying potential therapeutic strategies to combat them.
Check Digit Verification of cas no
The CAS Registry Mumber 1047645-82-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,4,7,6,4 and 5 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1047645-82:
(9*1)+(8*0)+(7*4)+(6*7)+(5*6)+(4*4)+(3*5)+(2*8)+(1*2)=158
158 % 10 = 8
So 1047645-82-8 is a valid CAS Registry Number.
1047645-82-8Relevant articles and documents
CRYSTALLINE N--5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide hydrochloride
-
Page/Page column 8-9, (2010/08/08)
An improved AKT inhibiting compound, crystalline N-{(1S)-2-amino-1-[(3-fluorophenyl)methyl]ethyl}-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide hydrochloride.
