1048027-81-1Relevant articles and documents
Carbonyl propargylation from the alcohol or aldehyde oxidation level employing 1,3-enynes as surrogates to preformed allenylmetal reagents: A ruthenium-catalyzed C-C bond-forming transfer hydrogenation
Patman, Ryan L.,Williams, Vanessa M.,Bower, John F.,Krische, Michael J.
supporting information; experimental part, p. 5220 - 5223 (2009/04/11)
(Chemical Equation Presented) Transcending oxidation level: Under the conditions of ruthenium-catalyzed transfer hydrogenation, conjugated enynes couple to benzylic, allylic, and aliphatic alcohols or aldehydes to furnish products of carbonyl propargylation (see scheme; dppf = 1,1′- bis(diphenylphosphino)ferrocene, TBS = tert-butyldimethylsilyl). Isotopic labeling studies corroborate a mechanism involving hydrogen donation from the alcohol to the enyne.
