104845-49-0

Basic information

• Product Name: Glycine, glycyl-L-phenylalanyl-L-leucyl-
• CAS NO: 104845-49-0
• Molecular Formula: C19H28N4O5
• Molecular Weight: 392.455
• Mol File: 104845-49-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Glycine, glycyl-L-phenylalanyl-L-leucyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Glycine, glycyl-L-phenylalanyl-L-leucyl-(104845-49-0)
• EPA Substance Registry System: Glycine, glycyl-L-phenylalanyl-L-leucyl-(104845-49-0)

Safety Data

• Hazardous Substances Data: 104845-49-0(Hazardous Substances Data)

Upstream product

• 29022-11-5 N-(fluoren-9-ylmethoxycarbonyl)glycine 
• 35661-60-0 Fmoc-Leu-OH 
• 35661-40-6 N-Fmoc L-Phe 
• 674333-00-7 N-chloroacetyl-Phe-Leu-Gly 

Downstream Products

• 305344-57-4 C₃₃H₄₅Cl₂N₅O₆ 
• 1204326-25-9 methotrexate-GFLG 

Relevant articles and documents

Biodegradable star HPMA polymer conjugates of doxorubicin for passive tumor targeting

New biodegradable star polymer-doxorubicin (Dox) conjugates designed for passive tumor targeting were investigated and the present study described their synthesis, physico-chemical characterization, drug release and biodegradation. In the conjugates the core formed by poly(amido amine) (PAMAM) dendrimers was grafted with semitelechelic N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers bearing doxorubicin attached by hydrazone bonds, which enabled intracellular pH-controlled drug release, or by a GFLG sequence, which was susceptible to enzymatic degradation. The controlled synthesis utilizing semitelechelic copolymer precursors facilitated preparation of biodegradable polymer conjugates in a broad range of molecular weights (110-295 kDa) while still maintaining low polydispersity (～1.7). The polymer grafts were attached to the dendrimers either through stable amide bonds or enzymatically or reductively degradable spacers, which enabled intracellular degradation of the high molecular weight polymer carrier to products that were able to be excreted from the body by glomerular filtration. Biodegradability tests showed that the rate of degradation was much faster for reductively degradable conjugates (completed within 4 h) than the degradation of conjugates linked via an enzymatically degradable oligopeptide GFLG sequence (within 72 h). This finding was likely due to the difference in steric hindrance for the small molecule glutathione and the enzyme cathepsin B. As for drug release, the conjugates were fairly stable in buffer at pH 7.4 (model of blood stream) but released doxorubicin either under mild acidic conditions or in the presence of lysosomal enzyme cathepsin B, both of which modeled the tumor cell microenvironment.

Method for synthesizing peptides comprising at least one glycine molecule

Method for preparing a peptide or a peptide derivative comprising at least 2 enantiopure amino acids and at least one glycine molecule, comprising the reaction of a compound of general formula XCH2—C(═O)—HN—A—COOY (II) with a compound of genera