1048955-49-2

Basic information

• Product Name: 8-cyclohexyl-1,3-diethyl-1H-purine-2,6(3H,7H)-dione
• Synonyms: 8-cyclohexyl-1,3-diethyl-1H-purine-2,6(3H,7H)-dione
• CAS NO: 1048955-49-2
• Molecular Weight: 290.365
• Mol File: 1048955-49-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 8-cyclohexyl-1,3-diethyl-1H-purine-2,6(3H,7H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 8-cyclohexyl-1,3-diethyl-1H-purine-2,6(3H,7H)-dione(1048955-49-2)
• EPA Substance Registry System: 8-cyclohexyl-1,3-diethyl-1H-purine-2,6(3H,7H)-dione(1048955-49-2)

Safety Data

• Hazardous Substances Data: 1048955-49-2(Hazardous Substances Data)

Upstream product

• 52998-22-8 5,6-diamino-1,3-diethyluracil 
• 2043-61-0 cyclohexanecarbaldehyde 

Relevant articles and documents

Synthesis of 8-substituted xanthines via 5,6-diaminouracils: an efficient route to A2A adenosine receptor antagonists

A one-pot route to 8-substituted xanthines has been developed from 5,6-diaminouracils and carboxaldehydes. The process, promoted by (bromodimethyl)sulfonium bromide, is mild and efficient and eliminates the need for external oxidants. Yields are good and the process is applicable to a range of substrates including a family of A2A adenosine receptor antagonists. Preparation of a new analog of the antagonist KW-6002 is presented, and in situ bromination of aryl substituted products demonstrated.