1049019-27-3

Basic information

• Product Name: 4-hydroxymethylidene-2-phenyl-4,5-dihydrooxazol-5-one
• Synonyms: 4-hydroxymethylidene-2-phenyl-4,5-dihydrooxazol-5-one
• CAS NO: 1049019-27-3
• Molecular Weight: 189.17
• Mol File: 1049019-27-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-hydroxymethylidene-2-phenyl-4,5-dihydrooxazol-5-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-hydroxymethylidene-2-phenyl-4,5-dihydrooxazol-5-one(1049019-27-3)
• EPA Substance Registry System: 4-hydroxymethylidene-2-phenyl-4,5-dihydrooxazol-5-one(1049019-27-3)

Safety Data

• Hazardous Substances Data: 1049019-27-3(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 182930-16-1 (Z)-4-(N,N-dimethylaminomethylene)-2-phenyl-2-oxazolin-5-one 
• 125008-68-6 methyl (Z)-2-benzoylamino-3-dimethylaminopropenoate 
• 64-17-5 ethanol 

Downstream Products

• 171616-91-4 (Z)-4-(acetoxymethylene)-2-phenyl-5(4H)-oxazolone 
• 220000-27-1 ethyl 2-benzoylamino-3-(phenylhydrazono)propanoate 
• 220000-37-3 ethyl 2-benzoylamino-3-[(4-chlorophenyl)hydrazono]propanoate 
• 220000-28-2 ethyl 2-benzoylamino-3-[(2-fluorophenyl)hydrazono]propanoate 
• 220000-34-0 ethyl 2-benzoylamino-3-[(3-methylphenyl)hydrazono]propanoate 
• 220000-39-5 ethyl 2-benzoylamino-3-[(4-methylphenyl)hydrazono]propanoate 
• 220000-33-9 ethyl 2-benzoylamino-3-[(3-bromophenyl)hydrazono]propanoate 
• 220000-29-3 ethyl 2-benzoylamino-3-[(2-chlorophenyl)hydrazono]propanoate 
• 220000-30-6 ethyl 2-benzoylamino-3-[(2-bromophenyl)hydrazono]propanoate 
• 220000-40-8 ethyl 2-benzoylamino-3-{[(4-trifluoromethyl)phenyl]hydrazono}propanoate 
• 495-69-2 Hippuric Acid 

Relevant articles and documents

Unusual reactions of 2-aryl-4-(N,N-dimethylaminomethylene)-2-oxazolin5-ones with O-nucleophiles: Synthesis of 2-aryl-4-hydi oxymethylene- 2-oxazolin-5-ones

The reactions of 2-aryl-4-(N,N-dimethyIaminomethylene)-2- oxazolin-5-ones 2 with aqueous or ethanolic KOH and sodium ethoxide lead to the formation of 2-aryl-4-hydroxymethylene-2-oxazolin-5ones 4, 1,5-bond remaining unaffected. However, the reactions of 2 with aqueous or methanolic KOH afford methyl 2-acylamino-3-dimethylaminopropenoates 9 along with 4. These observations are explained by the hard-soft acid-base (HSAB) principle. Further, compounds 9 on treatment with POCl3 in pyridine and ethanolic KOH give the corresponding cyclized products 2 and 4, respectively.