104917-09-1

Basic information

• Product Name: N-(7-chloro-1,8-naphthyridin-2-yl)benzamide
• Synonyms: N-(7-chloro-1,8-naphthyridin-2-yl)benzamide
• CAS NO: 104917-09-1
• Molecular Weight: 283.717
• Mol File: 104917-09-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(7-chloro-1,8-naphthyridin-2-yl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(7-chloro-1,8-naphthyridin-2-yl)benzamide(104917-09-1)
• EPA Substance Registry System: N-(7-chloro-1,8-naphthyridin-2-yl)benzamide(104917-09-1)

Safety Data

• Hazardous Substances Data: 104917-09-1(Hazardous Substances Data)

Upstream product

• 98-88-4 benzoyl chloride 
• 15944-33-9 2-chloro-7-amino-1,8-naphthyridine 

Downstream Products

• 103255-66-9 2-(7-chloro-1,8-naphthyridin-2-yl)-3-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)carbonylmethylisoindolin-1-one 

Relevant articles and documents

Multicomponent Synthesis of Isoindolinones by RhIII Relay Catalysis: Synthesis of Pagoclone and Pazinaclone from Benzaldehyde

A practical one-pot isoindolinone synthesis enabled by RhIII catalysis was developed. The advantage of this protocol is that it does not require pre-preparation of amide substrates, because RhIII participates in two reactions independently. This mild, operationally multicomponent process transforms a wide variety of commercially available aldehydes into the corresponding γ-lactams in good yields, thereby demonstrating that N-pyridin-2-yl benzamide is an effective directing group. Notably, the anxiolytic drugs pagoclone and pazinaclone can be directly prepared by this methodology.