104921-27-9

Basic information

• Product Name: 17β-hydroxy-5β,17α-pregn-20-yno<3,4-c>-1',2',5'-oxadiazole
• Synonyms: 17β-hydroxy-5β,17α-pregn-20-yno<3,4-c>-1',2',5'-oxadiazole
• CAS NO: 104921-27-9
• Molecular Weight: 340.466
• Mol File: 104921-27-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 17β-hydroxy-5β,17α-pregn-20-yno<3,4-c>-1',2',5'-oxadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 17β-hydroxy-5β,17α-pregn-20-yno<3,4-c>-1',2',5'-oxadiazole(104921-27-9)
• EPA Substance Registry System: 17β-hydroxy-5β,17α-pregn-20-yno<3,4-c>-1',2',5'-oxadiazole(104921-27-9)

Safety Data

• Hazardous Substances Data: 104921-27-9(Hazardous Substances Data)

Upstream product

• 2141-17-5 4-hydroxytestosterone 

Relevant articles and documents

Steroids and Related Studies: Part 78 - 17α-Pregn-20-yno-1',2',5'-oxadiazol-17-ols

5β,17α-Pregn-20-yno-1',2',5'-oxadiazol-17-ol (3) and its 5α-epimer (4) have been prepared for testing their anti-fertility profiles. 5β/α-Androstano-1',2',5'-oxadiazol-17-ones (5 and 6) needed for the purpose have been synthesised by two routes. 4,17β-Dihydroxy-4-androsten-3-one (10) obtained from testosterone is converted into its dioxime (11) which on heating with potassium hydroxide in ethylene glycol affords the oxadiazoles (12 and 13).Jones' oxidation of 12/13 furnish 5/6.In the other route, (25R)-3,4-dioximino-5ξ-spirostane (14) obtained from diosgenin is converted into spirostanoxadiazoles (15 and 16) which on Marker degradation, rearrangement of the 16-en-20-oximes and hydrolysis afford 5/6. 5/6 on ethynylation yield 3/4.