1049762-81-3

Basic information

• Product Name: 1-(2-chloroethyl)-2-methyl-5-nitro-1H-imidazole hydrochloride
• CAS NO: 1049762-81-3
• Molecular Weight: 226.062
• Mol File: 1049762-81-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-(2-chloroethyl)-2-methyl-5-nitro-1H-imidazole hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-chloroethyl)-2-methyl-5-nitro-1H-imidazole hydrochloride(1049762-81-3)
• EPA Substance Registry System: 1-(2-chloroethyl)-2-methyl-5-nitro-1H-imidazole hydrochloride(1049762-81-3)

Safety Data

• Hazardous Substances Data: 1049762-81-3(Hazardous Substances Data)

Usage

Description

1-(2-chloroethyl)-2-methyl-5-nitro-1H-imidazole hydrochloride is a chemical compound derived from imidazole, featuring a nitro group and a chloroethyl group. It possesses strong pharmacological properties and is known for its potent antitumor and antimicrobial activities, making it a valuable compound in the development of chemotherapy drugs and antibiotics.

Uses

Used in Pharmaceutical Industry:
1-(2-chloroethyl)-2-methyl-5-nitro-1H-imidazole hydrochloride is used as an active pharmaceutical ingredient for its potent antitumor and antimicrobial properties. Its ability to act as an alkylating agent allows it to effectively bind to DNA and interfere with cell replication, which is crucial in the treatment of cancer.
Used in Development of Chemotherapy Drugs:
1-(2-chloroethyl)-2-methyl-5-nitro-1H-imidazole hydrochloride is used as a key component in the development of chemotherapy drugs due to its strong antitumor activity. It modulates various cellular pathways, contributing to the inhibition of tumor growth and progression.
Used in Development of Antibiotics:
1-(2-chloroethyl)-2-methyl-5-nitro-1H-imidazole hydrochloride is also used in the development of antibiotics, leveraging its antimicrobial properties to combat bacterial infections.
Used in Drug Delivery Systems:
The hydrochloride salt form of 1-(2-chloroethyl)-2-methyl-5-nitro-1H-imidazole enhances the solubility of the compound in water, which is beneficial for the development of drug delivery systems. This improved solubility can lead to better bioavailability and therapeutic outcomes when used in pharmaceutical formulations.

Upstream product

• 443-48-1 metronidazole 

Relevant articles and documents

In vitro evaluation and in vivo efficacy of nitroimidazole-sulfanyl ethyl derivatives against Leishmania (V.) braziliensis and Leishmania (L.) mexicana

The aim of this study was to synthesize several small molecules of the type 5-nitroimidazole-sulfanyl and evaluate biological properties against the main Leishmania species that cause cutaneous leishmaniasis in Venezuela. Final compounds 4–7 were generated through simple nucleophilic substitution of 1-(2-chloroethyl)-2-methyl-5-nitroimidazole 3 with 2-mercaptoethanol, 1-methyl-2-mercaptoethanol, and 2-thyolacetic acid derivative. Compound 8 was synthesized via a coupling reaction between 7 and (S)-Methyl 2-amino-4-methylpentanoate hydrochloride. The inhibitory concentrations of (3, 4, 7, 8) against Leishmania (L.) mexicana and (V.) braziliensis in promastigotes and experimentally infected macrophages were determined by in vitro activity assays. Compounds 7 and 8 shown high activity against both species of Leishmania and were selected for the in vivo evaluation. Animals were infected with promastigotes of the two species and divided into four groups of ten (10) animals and a control group. Intralesional injection way was used for the treatment. The parasitological diagnostic after treatment was obtained by PCR using species specific oligonucleotides. The two Leishmania species were susceptible to compounds 7 and 8 in vivo assays. The results indicated that both compounds reduce significantly (96%) the size of the lesion and cure 63% of the mice infected with L (L) mexicana or L (V) braziliensis as was determined by PCR. The results are indicating that both compounds may represent an alternative treatment for these two Leishmania species.

Some nitroimidazole derivatives as possible antibacterial agents

In this study, six 1-[2(benzazol-2-yl)thioethy-2-methyl-5-nitroimidazole derivatives were synthesized. Antibacterial activities of the compounds obtained were examined and it was found that they are effective against aerobe bacteria.