105090-72-0Relevant articles and documents
Synthesis of racemic δ,δ-dimethylproline derivatives
Rodriguez, Isabel,Calaza, M. Isabel,Cativiela, Carlos
, p. 1093 - 1099 (2013/03/28)
A versatile methodology for the preparation of racemic δ,δ- dimethylproline derivatives has been developed. Methyl N-Boc-δ,δ- dimethylprolinate was synthesized from a β-amino acid in six steps and 55 % overall yield. The route is amenable to the preparation of a broad range of δ,δ-disubstituted prolines by starting with the adequate β-amino acids. In addition, one of the intermediate compounds in the synthetic route has been used for the preparation of a δ,δ- dimethylproline derivative that is substituted at the β-position with a phenyl group. This has been achieved by coupling phenylboronic acid with a regioselectively generated vinyl triflate followed by a stereoselective hydrogenation. δ,δ-Dimethylproline derivatives have been efficiently synthesized by employing a β-amino acid as the starting material. The methodology is amenable to the preparation of other δ,δ- disubstituted prolines. Copyright
Structure stability/activity relationships of sulfone stabilized N,N-dichloroamines
Low, Eddy,Kim, Bum,Francavilla, Charles,Shiau, Timothy P.,Turtle, Eric D.,O'Mahony, Donogh J.R.,Alvarez, Nichole,Houchin, Ashley,Xu, Ping,Zuck, Meghan,Celeri, Chris,Anderson, Mark B.,Najafi, Ramin,Jain, Rakesh K.
scheme or table, p. 3682 - 3685 (2011/08/06)
Structure stability/activity relationships (SXR) of a new class of N,N-dichloroamine compounds were explored to improve antimicrobial activity against Escherichia coli, Staphylococcus aureus, and Candida albicans while maintaining aqueous solution stability. This study identified a new class of solution-stable and topical antimicrobial agents. These agents are sulfone-stabilized and possess either a quaternary ammonium or sulfonate appendages as a water solubilizing group. Several unique challenges were confronted in the synthesis of these novel compounds which are highlighted in the discussion.
N-HALOGENATED AMINO COMPOUNDS AND DERIVATIVES
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Page/Page column 84, (2008/12/07)
The present invention relates to active bactericidal, antibacterial, anti-infective, antimicrobial, sporicidal, disinfectant, antifungal and antiviral compounds and compositions and to new uses of these compositions in therapy. This specification also describes methods of use for the new compounds and compositions. The specification further describes methods for preparing these compounds.